Efficacy of Oral Brush Cytology in the Evaluation of Oral Premalignant Lesions: A Multiple Cohort Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: The Oral Brush Cytology using Liquid Based Cytology technique has been developed to improve efficacy of conventional cytology. Our oobjectives were to statistically prove its usefulness to diagnose premalignant and malignant oral cavity lesions in presence of clinical evidence. Material and methods: 200 patients in 2 groups, 100 in each group with clinically diagnosed oral premalignant and malignant lesions respectively were selected. An oral brush cytology (LBC technique) followed by incisional biopsy were performed for every patient. Considering the histopathological diagnosis as the gold standard, the cytopathological scores were compared using statistical analysis of the samples. Results: In premalignant cases, 86% cases were male and 14% were female, while in malignant lesions, 91% patients were males, and 9% were females. Older age group especially of 31-50 years was predominantly affected (68% of premalignant cases, 56% of malignant cases). Oral submucous fibrosis fallowed by leukoplakia were found to be most common premalignant lesions. Buccal mucosa for premalignant and tongue for malignant lesions were found to be the most common site involved. Either tobacco chewing or smoking or both were found to be most common predisposing habits for both premalignant and malignant lesions. Well differentiated Squamous Cell Carcinoma was diagnosed to be most common malignant lesion. The sensitivity, specificity, PPV and NPV of brush cytology were 94.7%, 91.4%, 91.8% and 94.5%, respectively. Conclusions: The brush cytology using LBC technique is a noninvasive, inexpensive and reliable diagnostic tool which has a statistically significant specificity and sensitivity to diagnose dysplasia in early oral premalignant and malignant lesions where the treatment is most effective. Thus its use has the potential to reduce the poor mortality rate associated with oral malignancies.
Authors and Affiliations
Abhay Kumar, Ashwini Kumar, Mhd. Ziya
Keywords
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