EFFICACY OF SINGLE-DOSE OF DEXAMETHASONE IN REDUCTION OF PAIN, NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY- A RANDOMISED CONTROLLED TRIAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 35
Abstract
BACKGROUND Dexamethasone is an available and cheap drug and has low complications. There are not enough studies on antiemetic and analgesic effects of dexamethasone after laparoscopic cholecystectomy. The aim of this study was to assess the efficacy of single-dose of dexamethasone on Postoperative Pain (POP) and Nausea and Vomiting (PONV) in the patients undergoing laparoscopic cholecystectomy in northern Iran. MATERIALS AND METHODS This randomised controlled trial was conducted on 140 patients who were candidates for laparoscopic cholecystectomy. The subjects were randomly assigned into Group I (dexamethasone 8 mg) and Group II (normal saline 5 mL). Each group had 70 patients. The subjects were followed about POP and PONV every 4 hours for 12 hours after the operation using Nausea and Vomiting Scale (NVS) and Visual Analogue Scale (VAS) pain scores. RESULTS Seven patients (12.1%) were men and 123 (87.9%) were women. The mean age was 44.37 ± 8.69 years old. The mean NVS score was significantly different between the two groups in both periods 0 - 4 hours (Group I: 1.06 ± 0.85, Group II: 1.38 ± 1.00; p= 0.043) and 4 - 8 (Group I: 0.58 ± 0.24, Group II: 0.67 ± 0.29; p= 0.047) hours after the surgery. About VAS pain score, there were significant mean differences between the two groups in both periods 4 - 8 hours (Group I: 4.09 ± 1.01, Group II: 4.49 ± 1.24; p= 0.038) and 8 - 12 hours (Group I: 2.06 ± 0.81, Group II: 2.47 ± 1.16; p= 0.017) after the surgery. CONCLUSION According to the findings, single-dose of dexamethasone had a significant reducing effect on POP and PONV in the patients undergoing laparoscopic cholecystectomy.
Authors and Affiliations
Hossein Emami, Novin Nikbakhsh, Bahman Hassan Nassab, Soraya Khafri, Ali Asghar Darzi
Keywords
Related Articles
- EP ID EP544791
- DOI 10.14260/jemds/2018/858
- Views 83
- Downloads 0
ARTIFICIAL TEAR SUBSTITUTES: WHICH ONE & WHEN?
Dry eye is a multi-factorial disease; the therapy should improve the symptoms and signs of dry eye as well as address the underlying pathophysiology of the disease. Artificial tear substitutes have been used fo...
A COMPARATIVE STUDY OF LAPAROTOMY WOUND CLOSED WITH PROFESSOR HUGHES FAR NEAR TECHNIQUE WITH NYLON AND INTERRUPTED-X TECHNIQUE WITH VICRYL
BACKGROUND There is a debate about the best method of closure of midline vertical laparotomy wound following exploratory laparotomy. This debate has gained importance because one common complication of exploratory laparo...
A STUDY ON THE DETECTION OF BIOFILM FORMATION BY MULTIDRUG RESISTANT UROPATHOGENIC ISOLATES IN A TERTIARY CARE HOSPITAL
BACKGROUND Urinary Tract Infections (UTI) are the most common and important nosocomial infections, especially among diabetic patients. Emergence of multi-drug resistance and biofilm formation by these pathogens lead to c...
BACTERIAL PROFILE AND DRUG SUSCEPTIBILITY PATTERN OF URINARY TRACT INFECTION IN INFANTS AND CHILDREN
BACKGROUND The biggest concern over UTIs in children is that they can cause permanent kidney damage and scarring. Repeated scarring can lead to high blood pressure and reduced kidney function including kidney fa...