Efficacy of Somatostatin Analogues Combined With Conventional Treatment Versus Conventional Treatment For Adhesive Intestinal Obstruction: A Meta-Analysis In China
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Aim: To assess the efficacy of somatostatin analogues combined with conventional treatment as compared to conventional treatment for adhesive intestinal obstruction. Methods: The Cochrane Library, Embase, Pubmed, Web of science, VIP, and Wanfang databases were systematically searched to select the relevant randomized controlled trials (RCT) and quasi-RCT. Study quality was assessed; relevant data were extracted. Inter-study heterogeneity was assessed using the Cochran Q test, I 2 test, and the Galbraith figure. The source of heterogeneity was determined using subgroup and sensitivity analyses. Publication bias was tested using funnel plots; funnel plot asymmetry was tested using Egger’s and Begg’s tests. Results: Sixteen RCT including 1460 patients were included in this meta-analysis. The somatostatin group had obvious advantages in: (1) duration of abdominal pain and abdominal distension; (2) time of abdominal pain relief; (3) gastrointestinal decompression drainage amount; (4) hospitalization time. Following subgroup analysis based on somatostatin administration routes, i.e., subcutaneous injection and intravenous infusion, the somatostatin group had advantages for: (5) rate of conversion to surgery; (6) rate of effectiveness. The two groups had identical time of abdominal distension relief. Conclusions: Somatostatin analogues combined with conventional treatment is superior to conventional treatment alone for intestinal obstruction. Keywords: Adhesive intestinal obstruction; somatostatin；conventional treatment；efficacy；meta-analysisAim: To assess the efficacy of somatostatin analogues combined with conventional treatment as compared to conventional treatment for adhesive intestinal obstruction. Methods: The Cochrane Library, Embase, Pubmed, Web of science, VIP, and Wanfang databases were systematically searched to select the relevant randomized controlled trials (RCT) and quasi-RCT. Study quality was assessed; relevant data were extracted. Inter-study heterogeneity was assessed using the Cochran Q test, I 2 test, and the Galbraith figure. The source of heterogeneity was determined using subgroup and sensitivity analyses. Publication bias was tested using funnel plots; funnel plot asymmetry was tested using Egger’s and Begg’s tests. Results: Sixteen RCT including 1460 patients were included in this meta-analysis. The somatostatin group had obvious advantages in: (1) duration of abdominal pain and abdominal distension; (2) time of abdominal pain relief; (3) gastrointestinal decompression drainage amount; (4) hospitalization time. Following subgroup analysis based on somatostatin administration routes, i.e., subcutaneous injection and intravenous infusion, the somatostatin group had advantages for: (5) rate of conversion to surgery; (6) rate of effectiveness. The two groups had identical time of abdominal distension relief. Conclusions: Somatostatin analogues combined with conventional treatment is superior to conventional treatment alone for intestinal obstruction.
Authors and Affiliations
Haiyang Yua, Youquan Shi, Jixiang Chen, Dong Tang, Qingquan Xiong, Yuqin Huang, Daorong Wang
Keywords
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