EFFICACY OF STEM OF AMORPHOPHALLUS PAEONIIFOLIUS ON ANTI HYPERLIPIDEAMIC ACTIVITY
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 10
Abstract
This study was an experimental study conducted in 9 Wistar albino rats in Trincomalee Campus, Eastern University of Sri Lanka. Hyperlipideamia has been ranked as one of the greatest risk factors contributing to prevalence & severity of coronary heart disease. Globally, a third of Ishemic Heart Disease is attributable to high cholesterol level. Plant Amorphophallus paeoniifolius is a perennial herb belongs to the family of Araceae. In Tamil it’s known as Karunai kilangu. The stem of this plant traditionally claims antihyperlipideamic activity. As per the Siddha theory Kozhupu and Iyam mihu gunam results Adimedhai noi. However the antihyperlipideamic property of stem of the plant Amorphophallus paeoniifolius has not been proven yet. Thereby the present study deals with the efficacy of stem powder of plant Amorphophallus paeoniifolius in lowering the elevated lipid levels. Adult male Albino rats of weighing around 200-350gm obtained. The animals housed in polypropylene cages (three in each cage) under standard laboratory condition. Hyperlipideamia induced by intraperitoneal injection of Triton-X-100 (100mg/kg) after overnight fasting for 18 hours. The rats were divided into 3 groups 3 animals in each. Administered normal water and pellet for control group, standard group fed with Atorvastatin (10mg/kg) and test group fed with hot extract of stem of plant Amorphophallus paeoniifolius. After 72 hours of injection baseline cholesterol was evaluated, after treatment with drug for a week on 8th day blood withdrawal done for the analysis. Biochemical estimation carried out and result analyzed using simple statistical method. Study showed, after the Trion-X-100 injection there is increase in Total Cholesterol level and reduction in HDL level and Artherogenic index. After the administration of test and standard drug there is reduction in Total Cholesterol level, increase in HDL level, Reduction in both weight and AI index. The quotation for general character of Amorphophallus paeoniifolius is proven scientifically from the above scientific study for hyperlipideamia.
Authors and Affiliations
K. Bavithra
Keywords
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