Efficiency of Akkermansia muciniphila in type 2 diabetes and obesity
Journal Title: Journal of Current Biomedical Reports - Year 2020, Vol 1, Issue 1
Abstract
Akkermansia muciniphila is an anaerobic species of gut microbiome that has been proposed as a new functional microbiota with probiotic properties. Recent research has shown the amazing abilities of probiotic bacteria, A. muciniphila, which resides in most people's intestines. These bacteria affect the body if it increases or decreases abdominal fat. The presence of A. muciniphila has opened new ways for the use of this plentiful intestinal symbiont in next-generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is particularly effective in increasing mucosal thickness and enhancing bowel barrier function. As a result, host metabolic markers improve. The host functions that are disrupted in various diseases with a particular focus on metabolic disorders in animals and humans. A specific protein in the outer membrane of A. muciniphila called Amuc-110 could in the future be a strong candidate for drug production. As a result, we suggest that microbes and our microbiology or gut microbiome knowledge could be a new source for future treatments. The objectives of this review are to summarize the data available on the distribution of A. muciniphila gut in health and disease, to provide insights into the environment and its role in the creation of microbial networks at the mucosal interface, as well as to discuss recent research on its role in regulation.
Authors and Affiliations
Farzaneh Mohammadzadeh Rostami, Saman Shalibeik, Bahram Nasr Esfahani
Keywords
Related Articles
- EP ID EP688953
- DOI -
- Views 291
- Downloads 0
Detection of carbapenem resistance and virulence genes among Acinetobacter baumannii isolated from hospital environments in center of Iran
Carbapenem-resistant Acinetobacter baumannii are the top urgent antibiotic resistance threat in the world. The aims of this study were the determination of carbapenem-resistant genes and virulence genes among isolates fr...
A light shining through darkness: probiotic against COVID-19
The colonic microbiota playa key role in human gastrointestinal tract physiology include maintaining homeostasis of the large bowel and modulating the host immune response. Lactic acid bacteria (LAB) especially Lacto...
HIV/AIDS awareness and attitude among factory workers in Shiraz, Iran
HIV has been introduced as a causative agent for AIDS which is still considered as a major health problem for the country and a burden on the health care system. Raising awareness and knowledge plays a critical role in c...
Identification of bacterial isolates from nasolacrimal duct infection in children with congenital nasolacrimal duct obstruction from Feiz teaching hospital, Isfahan
Dacryocystitis is a lacrimal sac and duct inflammation. It can be inherited or congenital. Two primary forms are acquired dacryocystitis, acute and chronic. The goal of this study is to recognize common bacteria causing...
Evaluation of the correlation between serum lipid characteristics of obese subjects and ADIPOQ gene rs266729 polymorphism in Chaharmahal and Bakhtiari Province of Iran
Obesity is a multifactorial disorder that is influenced by various factors such as behavior, diet, environment, metabolic and genetic. This disease is the result of an imbalance between energy absorption and expenditure....