Efficiency, safety and tolerability of a balanced solution of electrolytes and cytocholine (Neurocytyn) combination for patients with acute ischemic stroke
Journal Title: Український неврологічний журнал - Year 2018, Vol 0, Issue 1
Abstract
Objective — to study the efficacy and safety of the new form of cyticoline, dissolved in a balanced crystalloid solution for patients with acute ischemic stroke. Methods and subjects. The results of treatment of 61 patients (39 men and 22 women, mean age59.43 ± 3.24 ) with acute ischemic stroke were analyzed. 25 patients of the control group received standard therapy. 36 patients of the main group received a balanced crystalloid solution (Neurocytin, YuriaFarm, Ukraine) during 14 days in addition to the standard therapy. Brain bioelectric activity was studied using the bispectral index (BISindex); cerebral oxygenation was evaluated using the cerebral oxymetry (rSO2); the degree of neuronal damage was assessed by neuronspecific enolase (NSE) level. The functional status of patients was assessed using NIHSS, modified Rankin scale (mRS) and Bartel index on the 1st and 14th day of the survey. Results. Starting from the 3rd day of treatment, the BIS index in patients of the main group was by 38.5 % higher (p = 0.032), and on the 7th it was 56.6 % higher compared to the baseline (p < 0.001), in contradiction to patients of control group (p > 0.05), whose index significantly changed only on the 10th day (p = 0.003). Similar dynamics was observed in the cerebral oxymetry indices. While the first days the NSE level in all patients exceeded normal by 6.5 times (p < 0.001). Starting from the 3rd day, the NSE level in the main group decreased by 21.2 % (p = 0.008), and on the 14th day it was 32.5 % lower than the baseline. Conclusions. Early use of Neurocytin provides effective recovery due to citicoline pharmacological effects as well as the elimination of hemoconcentration and providing better conditions for cerebral perfusion. Clinical use of the new dosage form of cyticoline, dissolved in a balanced electrolyte solution, confirmed its good tolerance and high safety.
Authors and Affiliations
V. A. Gryb, I. I. Titov, G. S. Chmyr, V. R. Gerasymchuk
Keywords
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