Ehlers-Danlos Syndrome and Skin Grafting
Journal Title: Journal of Clinical & Medical Case Reports - Year 2015, Vol 2, Issue 1
Abstract
Ehlers-Danlos syndrome is a heritable connective tissue disorder with an estimated prevalence of one in 10,000 to 25,000 persons [1]. Using clinical phenotype, biochemical and molecular defects, as well as inheritance patterns, a total of 6 subtypes have been described [2]. Although its hallmark findings include severe joint laxity and hyperextensible skin, this condition is known to affect a variety of different organ systems, including the cardiovascular, gastrointestinal, and bronchopulmonary systems [3]. The underlying disorder is related to alterations of collagen type I, III, and V resulting in architectural changes and decreased cross-linking of collagen fibers [4]. This translates into decreased breaking strength of collagen with its clinical correlates being skin fragility, easy bruising, and susceptibility to minor trauma [3]. The concern for surgeons is primarily related to bleeding and poor wound healing, as patients with Ehlers-Danlos syndrome tend to develop wound dehiscence and delayed wound healing postoperatively [5,6].
Authors and Affiliations
Derrick C. Wan
The Novel Use of Subdermal Implant Containing Etonogestrel Progestogen (ImplanonR) for the Treatment of a Difficult and Recurrent Case of Abdominal Wall Endometriosis, a Case Report
Background: Abdominal wall endometriosis is to be found to increase due to the rapid increase of caesarean section rates. The Case: The author report a case of a 44 year old multiparous woman diagnosed with recurrent abd...
Avascular Necrosis of Femoral Head in a 45 year Old Man: A Case Study of an Unnoticed Sickle Cell Disease Patient
Background: Periodic, self-limited episodes of excruciating musculoskeletal pain punctuate the lives of patients with Sickle Cell Disease (SCD) right from childhood. It is very rare for individuals with SCD to be asympto...
Early-Infantile Galactosialidosis: Clinical and Radiological Findings
Galactosialidosis is a rare lysosomal storage disorder. Very few reports of the early-infantile (EIGS) form can be found in the literature. This form typically presents with prenatal non-immune fetal hydrops associated w...
Co-Infection of Cryptococcal and Multidrug Resistant Tuberculous Meningitis in Immunocompetent Patient
A rare, previously unreported case of concurrent central nervous system infection with Cryptococcus neoformans and multi-drug resistant Mycobacterium tuberculosis in a 27-year-old immunocompetent female patient who repor...
Small Bowel Lymphangioma - A Rare Cause of Small Bowel Bleeding
Lymphangiomas represent benign embryonic vascular malformations of the lymphatic architecture. A symptomatic small bowel lymphangioma in an adult is a rare finding. Here we present a case of a 93 year-old male who had a...