Ehlers-Danlos Syndrome and Skin Grafting
Journal Title: Journal of Clinical & Medical Case Reports - Year 2015, Vol 2, Issue 1
Abstract
Ehlers-Danlos syndrome is a heritable connective tissue disorder with an estimated prevalence of one in 10,000 to 25,000 persons [1]. Using clinical phenotype, biochemical and molecular defects, as well as inheritance patterns, a total of 6 subtypes have been described [2]. Although its hallmark findings include severe joint laxity and hyperextensible skin, this condition is known to affect a variety of different organ systems, including the cardiovascular, gastrointestinal, and bronchopulmonary systems [3]. The underlying disorder is related to alterations of collagen type I, III, and V resulting in architectural changes and decreased cross-linking of collagen fibers [4]. This translates into decreased breaking strength of collagen with its clinical correlates being skin fragility, easy bruising, and susceptibility to minor trauma [3]. The concern for surgeons is primarily related to bleeding and poor wound healing, as patients with Ehlers-Danlos syndrome tend to develop wound dehiscence and delayed wound healing postoperatively [5,6].
Authors and Affiliations
Derrick C. Wan
Keywords
Related Articles
- EP ID EP207590
- DOI 10.13188/2332-4120.1000004
- Views 139
- Downloads 0
Ehlers-Danlos Syndrome and Skin Grafting
Ehlers-Danlos syndrome is a heritable connective tissue disorder with an estimated prevalence of one in 10,000 to 25,000 persons [1]. Using clinical phenotype, biochemical and molecular defects, as well as inheritance pa...
Small Bowel Lymphangioma - A Rare Cause of Small Bowel Bleeding
Lymphangiomas represent benign embryonic vascular malformations of the lymphatic architecture. A symptomatic small bowel lymphangioma in an adult is a rare finding. Here we present a case of a 93 year-old male who had a...
Acute Kidney Injury in a Child with Paroxysmal Cold Haemoglobinuria
Paroxysmal cold haemoglobinuria (PCH) is characterised by intravascular haemolysis mediated by the Donath-Landsteiner (D-L) antibody. It accounts for up to forty percent of all cases of autoimmune haemolytic anaemia in c...
The Novel Use of Subdermal Implant Containing Etonogestrel Progestogen (ImplanonR) for the Treatment of a Difficult and Recurrent Case of Abdominal Wall Endometriosis, a Case Report
Background: Abdominal wall endometriosis is to be found to increase due to the rapid increase of caesarean section rates. The Case: The author report a case of a 44 year old multiparous woman diagnosed with recurrent abd...
Denture Tumor: The Uninvited Distress amongst the Geriatrics - A Case Report
Dentures are prosthetic devices constructed to aid as a replacement for the missing teeth. However, the problems come when there is no right fitting as it can turn into a potpourri of problems for the patient. Discomfort...