Ekspresja koreceptorów CD80 i CD86 na limfocytach B w przerosłych migdałkach gardłowych u dzieci chorych na wysiękowe zapalenie ucha środkowego
Journal Title: Otolaryngologia Polska - Year 2010, Vol 64, Issue 2
Abstract
Aim: The aim of this study was evaluation of the percentage and mean fluorescence intensity of lymphocytes B with expression CD80 and CD86 in hypertrophied adenoids in children with otitis media with effusion. Material and methods: Expression coreceptors CD80 and CD86 on lymphocytes B in adenoid tissue were estimated by flow cytometry method. 15 children with otitis media with effusion and 15 children with hypertrophied adenoid were tested. Results: This study showed significantly higher percentage of lymphocytes CD19+CD80+ in children with otitis media with effusion (OME 1,42% ± 0,91) than in comparative group with hypertrophied adenoids (AH 0,63% ± 0,21). The receptor CD86 didn’t show differences in expression on lymphocytes B between both examinated groups. Conclusion: Low expression of CD80 and CD86 indicates that local immunity response in hypertrophied adenods in children with otitis media with effusion is weakened. It can contribute to the otitis media with effusion.
Authors and Affiliations
Karol Ratomski, Beata Żelazowska-Rutkowska, Jolanta Wysocka, Bożena Skotnicka, Edwina Kasprzycka, Ilona Bauer
Keywords
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