Ekstrak Tempe Kedelai Hitam dan Ubi Jalar Ungu Terhadap Toleransi Darah Tikus Model DMT2
Journal Title: Biogenesis: Jurnal Ilmiah Biologi - Year 2018, Vol 6, Issue 1
Abstract
Diabetes mellitus tipe 2 (DMT2) disebabkan oleh penggunaan insulin yang kurang efektif oleh tubuh. DMT2 dengan hiperglikemia menyebabkan gangguan sistem sirkulasi yaitu terganggunya keseimbangan ion intraseluler sehingga menyebabkan perubahan ukuran sel dan kerapuhan membran sel. Tempe kedelai hitam dan ubi jalar ungu memiliki potensi terapi bagi penderita DMT2. Penelitian ini bertujuan mengetahui toleransi osmotik darah tikus model DMT2 yang diberikan perlakuan campuran ekstrak tempe kedelai hitam dan ubi jalar ungu. Toleransi osmotik ditunjukkan dengan tingkat kerusakan membran eritrosit yaitu krenasi dan hemolisis. Hasil penelitian menunjukkan bahwa pemberian senyawa kimia berupa glibenklamid bekerja lebih baik menurunkan kerusakan membran sel dibandingkan dengan pemberian senyawa alami campuran ekstrak tempe kedelai hitam dan ubi jalar ungu.
Authors and Affiliations
Mustika Ayu Wulansari, Sri Rahayu Lestari, Abdul Gofur
Keywords
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- EP ID EP383651
- DOI 10.24252/bio.v6i1.4236
- Views 183
- Downloads 0
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