The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes

The positive transcription elongation factor b (P-TEFb) is a heterodimeric complex composed of cyclin-dependent kinase 9 and its regulator cyclin T1/2. It stimulates transcription elongation by phosphorylation of serine...

Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

During the past decade, the lipid-raft hypothesis has focused attention on the role of membrane domains in controlling cellular functions. Among the best-studied roles of lipid rafts is the regulation of T-cell signallin...

T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation

T-cell antigen receptor triggering mechanisms and lipid rafts are of broad interest, but are also controversial topics. Here, we review some recent progress in these two research fields, which has been accomplished mostl...

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects' Review Series

Ubiquitin (Ub) is a small protein modifier that regulates many biological processes, including gene transcription, cell-cycle progression, DNA repair, apoptosis, virus budding and receptor endocytosis. Ub can be conjugat...

Are rafts involved in T-cell receptor signalling? Introduction to the Talking Point on the involvement of lipid rafts in T-cell activation