Electro diagnostic Evaluation of Autonomic Dysfunction in Diabetes Mellitus in Baghdad, Iraq
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 12
Abstract
Background:Diabetic autonomic neuropathy (DAN) is a serious and common complication of diabetes. The most studied and clinically important form of DAN is cardiovascular autonomic neuropathy. Aim of study:To assess the autonomic dysfunction in diabetics electrodiagnoctically using reliable tests by SSR and R-R interval tests. Patients and Methods: A cross-sectional study was conducted in the Electromyography unit in Baghdad Teaching Hospital between (Feb/1/2018 – May/15/2018). It included all adult male and female with symptoms of neuropathy or autonomic dysfunction. Pregnant women were excluded from the study. Neurological tests were performed as (Sympathetic Skin Response, and R-R interval including normal and deep breath, Valsalva and tilt tests). Results: Means of SSR amplitude, R-R interval (Valsalva), and R-R interval (tilt) tests were significantly higher in non-diabetic patients than diabetics (2.19 versus 0.541, P= 0.001; 1.75 versus 1.48, P= 0.017; and 1.44 versus 1.01, P= 0.002 respectively).They were also significantly higher in controlled than in uncontrolled diabetic patients (1.69 versus 0.15, P= 0.044; 1.99 versus 1.31, P= 0.039; and 1.23 versus 0.941, P= 0.022 respectively). Cut points of these tests between controlled and uncontrolled diabetic patients were (0.81, 1.84, and 1.04 respectively).This mean that all patients with testsbelow these values can be considered uncontrolled diabetics. Conclusion: SSR amplitude, and R-R interval tests are good electro diagnostic tests to evaluate the autonomic dysfunction affected by DM, and to assess the severity of autonomic dysfunction in uncontrolled DM and differentiating them from those with controlled DM.
Authors and Affiliations
NihalMohanad Lutfi, AbdulnasirHussin Ameer
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