Electrochemical Detection of Epinephrine in The Presence of Ascorbic Acid at Poly (p-Aminobenzene Sulfonic Acid) Modified Sensor
Journal Title: Cumhuriyet Science journal - Year 2018, Vol 39, Issue 4
Abstract
In this study, a rapid, reliable, selective and sensitive simultaneous voltammetric determination of Epinephrine (EP) in the presence of ascorbic acid at poly (p-aminobenzene sulphonic acid, ABSA) modified sensor was aimed. The glassy carbon electrode was successfully modified with ABSA in 0.1 M KCl solution by the cycling voltammetry technique. The sensor, modified with a polymeric thin film, showed excellent electrocatalytic activity against the oxidation of EP and ascorbic acid (AA). The results showed that the oxidation potential and current responses of EP and AA improved significantly. The modified sensor showed excellent response with limit of detection as 50 nM in the determination of EP at the 5.0 - 53.2 μM concentration range under optimum conditions. In real sample analyzes performed in pharmaceutical preparation and blood serum, recovery values were 77.3%-98.4%. The results obtained show that the modified sensor can be applied to the detection of EP in the presence of AA. The proposed sensor is promising for routine analysis because of its high selectivity, reproducibility, reproducibility and long-term stability characteristics and high recovery values obtained in pharmaceutical and biological samples.
Authors and Affiliations
Şevket Zişan Bilge YAĞCI, Ebru KUYUMCU SAVAN, Gamze ERDOĞDU
Keywords
Related Articles
- EP ID EP488409
- DOI 10.17776/csj.426874
- Views 33
- Downloads 0
Determination of Trace Levels of Nitrite in Beverages Samples Through Micellar Improved Catalytic Kinetic Spectrophotometry
In this study, a simple and sensitive catalytic kinetic spectrophotometry method for determination of nitrite has been described. The method is based on the oxidation of chlorpromazine by nitrite in presence of mixed sur...
Experimental Investigation of Free Convection from Foam Heat Sinks in an Inclined Rectangular Channel
In this present study, free convection from an in-line 5x1 array of aluminum foam heat sinks which were placed on the bottom wall of the inclined rectangular channel was investigated. Aluminum foam heat sinks were made o...
Investigation of Wind Characteristics for Antalya Region by Using Weibull Distribution
The most widely used statistical method that is used to determine the wind energy potential for a specific region is Weibull distribution or probability function. Using two-parameter Weibull distribution function, wind c...
Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro
Immune system cells play a crucial role against different types and scales of danger in our body. Macrophages, one of the major innate immune system cells, can recognize the danger and produce different kinds of inflamma...
Gas Chromatography Method Validation Study for Sensitive and Accurate Determination of Volatile Aromatic Hydrocarbons (VAHs) in Water
A wide range of chemicals comes to exist at the end of the industrial activities. They could have highly toxic and carcinogenic effects on the human health and water environment. Therefore, these substances, which are li...