Electrochemical Determination of Rifampicin Based on Its Oxidation Using Multi-Walled Carbon Nanotube-Modified Glassy Carbon Electrodes
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 4
Abstract
Objectives: The aim of the study was to investigate the electrochemical behavior of rifampicin (RIF) in the anodic direction using multi-walled carbon nanotube (MWCNT)-modified glassy carbon electrodes. Materials and Methods: The anodic investigation of RIF was carried out with cyclic, differential pulse, and square wave voltammetry. A three-electrode system consisting of a glassy carbon electrode with a modification by MWCNTs as the working electrode, a platinum wire as the counter electrode, and an Ag/AgCl electrode as reference was used for the experiments. Results: The anodic process of RIF was irreversible and diffusion controlled. Linear responses were obtained between 0.04 and 10 μM for both techniques in acetate buffer (pH 3.5) as supporting electrolyte. The limit of detection values were 7.51 and 11.3 nM for differential pulse and square wave voltammetry, respectively. The repeatability, reproducibility, precision, and accuracy of the proposed methods were also investigated. Determination of RIF was carried out on its pharmaceutical dosage forms and the results were compared with those from other electrochemical sensors and the liquid chromatographic and spectrophotometric methods in the literature. Conclusion: These validated techniques provided selective, rapid, sensitive, precise, and cheap determination of RIF as alternative techniques to the liquid chromatographic and spectrophotometric methods in therapeutic drug monitoring.
Authors and Affiliations
Dilek KUL
Keywords
Related Articles
- EP ID EP688828
- DOI 10.4274/tjps.galenos.2019.33600
- Views 171
- Downloads 0
Phytotherapy as a Complementary Medicine for Multiple Sclerosis
Multiple sclerosis (MS) is the most common cause of neurologic disability in adults worldwide. Two main issues have caused MS patients to face several problems. One issue is that the definite cause of MS has not yet been...
Screening of Sacrificial Excipients for Arresting Devitrification of Itraconazole from Solid Dispersion
Objectives: The aim of the present investigation was to develop a solid dispersion of itraconazole (ITR) using sacrificial excipients like pregelatinized starch and spray-dried lactose alongside hydroxypropyl methylcellu...
Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles
Objectives: Azithromycin dihydrate is a macrolide antibiotic used for the treatment of several types of bacterial infections. The drug shows low oral bioavailability due to its low solubility. In the present work solid l...
Quantification of Galantamine in Sternbergia Species by High Performance Liquid Chromatography
Objectives: This study describes the qualitative and quantitative analysis of galantamine in Sternbergia species growing in Turkey. Materials and Methods: Galantamine was isolated from Sternbergia fischeriana bulbs and...
In Situ Absorption Study of Acebutolol by Modulating P-glycoprotein with Verapamil in Rats
Objectives: Acebutolol HCl (ABL) is a selective β-adrenergic receptor blocking agent that is preferably administered by the oral route despite its low bioavailability (30-50%). The purpose of this study was to evaluate t...