ELECTROCHEMICAL STUDIES OF MODIFIED 2-HYDROXYPROPYL BETA CYCLODEXTRIN AND MODIFIED CARBON NANOTUBES SENSORS FOR DETERMINATION OF ANTI-DIABETIC PIOGLITAZONE HYDROCHLORIDE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 2
Abstract
The present study aimed to suggest a simple, accurate and sensitive electrochemical method for the potentiometric determination of pioglitazone hydrochloride (PLZ). The developed method was conducted by the incorporation of PLZ with sodium tetraphenyl borate (TPB) to fabricate four PLZ-TPB sensors using o-nitrophenyloctyl ether (o-NPOE) as a plasticizer in a polymeric matrix polyvinyl chloride (PVC). Sensor I and sensor II were conventional coated wire membrane type, while sensor II was modified using 2-hydroxypropyl beta cyclodextrin (β-CD) as ionophore. Sensor III and sensor IV were carbon paste type and sensor IV was modified using carbon nanotubes (CNTs). Under optimum condition the proposed sensors displayed Nernstian responses of 53.8±0.8 and 55.5±0.6, 57.1±0.4 and 57.7±0.1 mV decade-1 for sensors I, II, III and IV, respectively at 25˚C over drug concentration ranges of 1.0×10-6-1.0×10-3 and 1.0×10-6-1.0×10-2 mol L-1, 1.0×10-7-1.0×10-2 and 1.0×10-8-1.0×10-2 mol L-1 with lower detection limits of 5.0 × 10-7, 4.7 ×10-7 and 5.0 ×10-8 and 4.8 ×10-9 mol L-1 for the four mentioned sensors, respectively. The selectivity of the proposed method towards the investigated drug and some possible interfering species was studied using a separate solution method. The effect of pharmaceutical additives and some related pharmacological action drugs was also tested. The developed method was validated and gave excellent results for the determination of PLZ in its pharmaceutical formulations and biological fluids.
Authors and Affiliations
Maha F. El-Tohamy
ANTICANCER ACTIVITY AND MOLECULAR DOCKING OF SOME SYNTHESIZED 2-THIOHYDANTOIN DERIVATIVES
Objective: the present work is designed for synthesis of a series of novel 2- thiohydantoin derivatives, description of the electron impact (EI) ionization mass spectral fragmentation patterns and evaluation of them agai...
CRITICAL REVIEW OF ANUKTA DRAVYA “LAHSUN BEL (MANSOA ALLIACEA)
Medicinal plants are scientifically documented in Ayurvedic literature based on the sound fundamentals of rasa (Taste), guna (Property), virya (Potency), vipaka (Metabolism) and prabhava (Specific action).Vedic to Samhit...
REVIEW ON ANTIDIABETIC DRUGS
Diabetes insipidus is the disorder that causes an imbalance of water in the body. The major complication is the dehydration leads to electrolyte imbalance. Following drugs desmopressin, vasopressin and hydrochlorothazide...
DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ROSUVASTATIN AND GLIBENCLAMIDE
A convenient and rapid reverse phase-HPLC (RP-HPLC) method has been developed and validated for simultaneous estimation of rosuvastatin (RSV) and glibenclamide (GBC) according to international conference on harmonization...
IDENTIFICATION OF FATTY ACIDS AND FATTY ACID ESTERS FROM ETHYL ACETATE BARK EXTRACT OF HOLOPTELEA INTEGRIFOLIA (ROXB.) PLANCH BY GC-MS
It is an ornamental plant with certain medicinal characteristics due to many valuable and active Phytoconstituents in various parts of the plant. Ethyl acetate extract of the bark was triturated with warm n-hexane and wa...