ELIMINACIJA INHIBITORA ANGIOTENZIN KONVERTUJUĆEG ENZIMA PUTEM PERITONEUMSKOG DIJALIZATA
Journal Title: Acta Medica Medianae - Year 2011, Vol 50, Issue 2
Abstract
Inhibitori angiotenzin–konvertujućeg enzima (ACE inhibitori) najčešće su propisivani antihipertenzivni lekovi. Iako pripadaju istoj grupi lekova i pokazuju sličnu kliničku efikasnost, pojedini ACE inhibitori imaju različite farmakološke osobine, što može biti posledica njihovih različitih hemijskih karakteristika. Jedna od najznačajnijih osobina biološki aktivnih supstanci je njihova lipofilnost. Ona utiče na njihovu apsorpciju, raspodelu u tkiva, aktivnost, eliminaciju. U ovom radu proučavana je eliminacija ACE inhibitora fosinoprila i cilazaprila dijalizatom kod bolesnika na peritoneumskoj dijalizi i uticaj lipofilnosti na ovaj put njihove eliminacije.
Authors and Affiliations
Jadranka Odović, Jasna Trbojević-Stanković
Keywords
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- EP ID EP113922
- DOI doi:10.5633/amm.2011.0202
- Views 82
- Downloads 0
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