EMBEDMENT TECHNIQUE: AN ALTERNATIVE TO WET GRANULATION FOR BETTER CONTROL OF RELEASE OF HIGHLY WATER SOLUBLE DRUGS–A CASE STUDY WITH DILTIAZEM HCl
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 12
Abstract
Objective: Extending or controlling the release of highly water soluble drugs from matrix tablets is always a challenge. The research attempt was aimed to explore the embedment technique for the development of extended release (ER) matrix tablets of highly water soluble drugs by taking Diltiazem HCl as a model drug.Methods: The matrix tablets were developed through embedding the drug in the polymer matrix followed by compression using hydroxypropyl methylcellulose (HPMC) K 4000, Eudragit RS PO as drug release-retarding polymers. Matrix tablets from the optimized formulations (F5 & F11) were also prepared by wet granulation method for comparing the efficiency of both the techniques for controlling the drug release.Results: The results of the dissolution studies indicated that the drug release could be controlled only up to 16 h with HPMC K 4000 alone (formulation F5), but upon incorporation of Eudragit RS PO, the drug release was extended up to 24 h (formulation F11). The matrix tablets from the same formulations, F5 and F11, prepared by wet granulation technique showed the drug release only up to 12 h and 20 h respectively. The drug release from these formulations followed first–order kinetics. The mechanism was found to be almost Higuchi’s diffusion along with some anomalous transport (non–Fickian diffusion).Conclusion: The embedding technique was found to be promising for the development of ER matrix tablets of highly water soluble drugs with lesser quantities of polymers.Â
Authors and Affiliations
Grandhi Srikar, Prameelarani Avula, Sriharsha Koreddi
Keywords
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