Emergencies in People with Hemophilia (PWH)
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: PWH will present with various bleeding emergencies. Management in resource poor setting is a challenge because majority cannot afford. Situation warrants usage of factor concentrates in minimum effective thrombotic doses. Current study aimed to see the various emergencies encountered in PWH. Material and Methods: We retrospectively collected data from case records of people with Hemophilia (PWH) who presented with bleeding emergencies over a period of one year. And the parameters studied were Age, sympotms, signs, riskfactors, investigations like ultrasound, CTScan, clotting factor assay, inhibitors, screening for transmitted infections like HIV, Hepatitis C, Hepatits B were done, treatment extended and outcome. Results: Total 66 of PWHcame with bleeding episodes in 1 year to emergency department. Average age was 23.95years. Hemophilia A in 58 and 8 were hemophilia B. Average body weight was 48.3kgs. Mild hemophiliacs were 6, moderate 27 and severe 33. Spontaneous bleeding episodes were noted in 44. Precipitating factors for bleeding were noted as injury in 14, intra-muscular injection 2, infection 2, tooth extraction, boil, and seizures in 1 each. Average duration of bleeding was 1.4 days. Conclusion: Minimum effective factor concentrates can bring gratifying results in majority. In certain situations higher doses are needed to stop the bleeding. Activated factor VII is an effective alternative in some PWH with inhibitors.
Authors and Affiliations
Mallikarjuna Shetty, Adiraju Krishna Prasad, Nageswar Rao Modugu
Keywords
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