Emergent of Colistin Resistant Enterobacteriaceae carrying the mcr-1 gene among clinical isolates from patients in an Argentine hospital: Clinical and microbiological aspects
Journal Title: Global Journal of Infectious Diseases and Clinical Research - Year 2018, Vol 4, Issue 1
Abstract
The recent emergence of multidrug-resistant (MDR) or extremely drug-resistant (XDR) Gram-negative bacteria has renewed interest in colistin (Polymyxins, a family of cationic polypeptide antibiotics) as a last-resort in the treatment of severe bacterial infections [1,2], despite being a drug with potential serious adverse events (mainly high risk of nephrotoxicity) [3,4]. Acquired resistance to polymyxins is generally associated with chromosomal mutations [5,6]. However, increasing use of this antibiotic in clinical and veterinary practice has led to the emergence of mobile colistin resistance genes, including mcr-1, which was first reported in Escherichia coli in 2015 in China [7], and mcr-2, identified in Escherichia coli in 2016 in Belgium [8]. Recently, three further plasmid mediated colistin resistance genes, mcr-3, mcr-4 and mcr-5, were identified, with Enterobacteriaceae being the predominant hosts (particularly Escherichia coli and Salmonella spp). Mcr-1 and mcr-2 are the most frequent variants found in human clinical isolates. [7-11].
Authors and Affiliations
J Nievas, D Torres, F Nicola, P Bonvehí, L Scocozza, W Alcalá, S Relloso
Keywords
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- EP ID EP533710
- DOI 10.17352/2455-5363.000019
- Views 69
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