Emerging Pattern of Salmonella typhi Drug Resistance
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 4
Abstract
Enteric fever is a global health problem. The burden of enteric fever is increasing especially in developing countries like India, coupled with increasing emergence of Multi-Drug Resistant typhoid infections. We in the present study tried to evaluate the predominant type of S.typhi and S.paratyphi A in the patients with febrile illness attending Kakatiya Medical College and Hospital, Warangal, Telangana. In total of 89 suspected cases of enteric fever blood cultures were done from the period from Feb 2011 to Dec 2012. Collected blood samples introduced into brain heart infusion broth incubated aerobically at 37°C and then incubated for 48 hours. Subcultures were then made on blood agar and MacConkey agar, 24Hrs after collection. Phage typing was done and the sensitivity to antibiotics was done by Kirby Bauer disc diffusion method. Salmonella typhi was found in 35 samples and the phage types were E1 in 31 samples (88.57%) and type A was found in 4 samples (11.43%) of cases. The common Biotype was typed I in 33 cases (94.29%) and 2 cases were of Biotype II (5.71%) of cases. Similarly, S. paratyphi A was found in 10 samples all the samples were untypable for phages. Majorities were found to resistant to Cotrimoxazole (86.67%) followed by 73.33% isolates were resistant to Erythromycin. The isolates were most sensitive to Ciprofloxacin followed by chloramphenicol and Ampicillin. The findings of the study indicate that the predominant S.typhi phage was E1 and all the E1 strains were belonging to Biotype I. Although there is considerable resistance seen to antibiotics like cotrimoxazole, Erythromycin, Gentamycin, Norfloxacin but the isolates were still found to the susceptible to ciprofloxacin and chloramphenicol. However, such studies must be conducted regularly in order to find if any change in pattern of resistance of isolated strains is found in the population and physicians should use antibiotics judiciously in order to prevent the development of more drug-resistant organisms.
Authors and Affiliations
Dr. S Ravinder, Dr. R Kondal Rao
Keywords
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