EMERGING TRENDS IN ORAL BIOAVAILABILITY ENHANCEMENT
Journal Title: International Journal of Drug Regulatory Affairs - Year 2013, Vol 1, Issue 2
Abstract
Oral route is one of the most accepted and convenient mode of drug administration, however low oral bioavailability of many drugs is a major concern which limits their oral administration. Optimum solubility and permeation of a drug across the intestinal epithelium is a prerequisite to reach the systematic circulation in the active form for effective action at the desired site. Physicochemical properties of the drug, physiological factors and pharmacokinetic factors are mainly responsible for their low solubility, low permeability and high metabolism which in turn into low oral bioavailability of the drug molecules. In this review, various factors which affect bioavailability of drugs and possible approaches to overcome this problem have been discussed. The review identifies various areas for research that can be focused for improving oral bioavailability of therapeutic molecules for different classes of drugs, thus making the oral route of administration of the drugs more effective and useful.
Authors and Affiliations
Talegaonkar S, Ahmad Z, Tariq M, Khan Z. I, Negi L. M
Keywords
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