EMRSA-15 Bacteremia is not Associated with a Worse Outcome Compared with Bacteremia Caused by Multidrug-Resistant MRSA
Journal Title: International Journal of Biomedical Science (IJBS) - Year 2007, Vol 3, Issue 2
Abstract
EMRS A-15 (ST 22-MRS A-IV) is rapidly replacing the endemic ST 239 health care-associated methicillin- resistant Staphylococcus aureus clone in Singapore. A one-year single-centre cohort study of inpatients with MRS A bacteremia was performed to determine if bacteremia caused by EMRS A-15 was associated with worse outcomes compared to bacteremia caused by the endemic ST239 strain. Strains were identified by antibiotypes, and subsequent validation was performed on a selected sample of MRS A strains via pulsedfield gel electrophoresis and staphylococcal chromosome cassette mec typing. Two hundred and twenty-eight patients with MRS A bacteremia were studied; Seventy-three were infected with EMRS A-15. EMRS A-15- and ST 239-infected patients were similar regarding gender, frequencies of most co-morbidities, and risk factors for adverse outcomes. Similar numbers of EMRS A-15-infected and ST 239-infected patients died (24.7% vs 27.1%, P=0.70) or developed complicated infections (41.1% vs 40.0%, P=0.88). After multivariate analysis, EMRSA-15 as a cause of bacteremia was not significantly associated with either death or development of complicated infections, although inappropriate therapy (5.45-fold, P
Authors and Affiliations
Paul Tambyah, Li-Yang Hsu, Mei-Ling Kang, Nidhi Loomba-Chlebicka, Tse-Hsien Koh, Ban-Hock Tan
Keywords
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