EMULSIFYING PROPERTIES OF AFZELIA GUM IN LIQUID PARAFFIN EMULSION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 11
Abstract
Objective: Afzelia africana gum has been shown to possess surface activity. It is a good alternative to sodium carboxy methylcellulose in terms of suspending properties. This work was aimed at evaluating the emulsifying properties of the gum in liquid paraffin emulsion.Methods: Liquid paraffin emulsions (200 ml each) were prepared with different concentrations (1, 2, 3, 5 and 10 % w/v) of afzelia gum as an emulsifying agent. Similar preparations containing standard acacia gum at corresponding concentrations were also made. Liquid paraffin emulsions (200 ml each) were equally prepared using 60 ml liquid paraffin as the oily phase and 6 g of various combinations of afzelia gum and tween 80 as emulsifier blends. The emulsifier blends were of ratio 1:5, 1:2, 1:1, 2:1 and 5:1. The preparations were assessed for density and viscosity; and then for stability after 5 d of storage.Results: The viscosity of emulsion containing 10 % w/v afzelia gum was 668.90 mPa.s while that of an emulsion containing the same concentration of acacia gum was 23.56 mPa. s. Emulsion containing 3 % w/v afzelia gum (having a creaming index of 16 %) was found to be more stable compared to the emulsion containing 10 % w/v acacia gum (having creaming index of 28 %). The viscosity and stability of emulsions containing emulsifier blends of afzelia gum and tween 80 increased with increase in the proportion of afzelia gum.Conclusion: The gum is suitable for use at a concentration of 3 % w/v as an emulsifier in 30 % v/v liquid paraffin emulsion, and it is about three times better than acacia gum as an emulsifier. It is a good alternative to standard acacia gum for emulsification.Â
Authors and Affiliations
Emmanuel O. Olorunsola, Stephen O. Majekodunmi
Keywords
Related Articles
- EP ID EP575907
- DOI 10.22159/ijpps.2016v8i11.14509
- Views 86
- Downloads 0
RELIABILITY AND VALIDITY OF HYPOTHETICAL SCENARIOS FOR ESTIMATING WILLINGNESS TO PAY (WTP) PER QUALITY ADJUSTED LIFE YEAR (QALY) IN INDONESIA SETTING
Objective: To estimate validity and reliability of WTP questionnaire which WTP value can be taken as an indication of the monetary value of health gains, which may carry information regarding the appropriate height of th...
INDIRECT SPECTROPHOTOMETRIC ESTIMATION OF DRUGS USING CERIUM (IV) AND RHODAMINE-B AS ANALYTICAL REAGENT
Objective: The object of this research was to develop simple, sensitive and selective methods for the quantitative determination of five drugs, viz., (RAM) Ramipril, (VOR) Voriconazole, (SDC) Sildenafil Citrate, (ITM) Im...
DEVELOPMENT AND EVALUATION OF SUBLINGUAL TABLET OF ZOLPIDEM TARTRATE AN ANTIPSYCHOTIC DRUG
Objective: The present work aims to develop and evaluate sublingual tablets of Zolpidem Tartrate used for the short-term treatment of insomnia.Methods: The tablet of Zolpidem Tartrate was prepared by direct compression t...
DEVELOPMENT AND IN VITRO-IN VIVO EVALUATION OF GLIPIZIDE LOADED MULTIUNIT PULSATILE FORMULATION FOR TREATMENT OF DIABETIC PATIENTS
The aim of the present study was to develop oral multiparticulate pulsatile drug delivery system for hypoglycemic agent ‘glipizide’. Time dependent rupturable system was selected for delivering glipizide in a pulsati...
ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF SELECTED MEDICINAL PLANTS AGAINST HUMAN ORAL PATHOGENS
Objective: The aim of the study was focused on determining the phytochemicals, antibacterial, antiadherence, antifungal and antioxidant activities of Glycyrrhiza glabra, Matricaria chamomilla and Eclipta alba and also th...