Enalapril enhances the anticonvulsant activity of lamotrigine in the test of maximal electroshock.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
The aim of this study was to find out whether angiotensin-converting enzyme (ACE) inhibitors, enalapril and cilazapril, affect the anticonvulsant action of some second-generation antiepileptics, lamotrigine (LTG), topiramate (TPM) and oxcarbazepine (OXC).
Authors and Affiliations
Krzysztof Łukawski, Tomasz Jakubus, Agnieszka Janowska, Grzegorz Raszewski, Stanisław Czuczwar
Urocortin: a protective peptide that targets both the myocardium and vasculature.
The urocortins are a family of endogenously produced peptide hormones that show great promise as potential drugs for the treatment of heart disease. They can increase contractility and cardiac output without causing chan...
Antihistaminic activity of carane derivatives in isolated guinea pig ileum.
Local anesthetics (LAs) inhibit membrane depolarization by reducing sodium and potassium conductance, and subsequent displacement of calcium ions from binding sites seems to occur. Histamine release appears to be a secre...
Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer's Disease.
Curcumin has been reported to inhibit the generation of Aβ, but the underlying mechanisms by which this occurs remain unknown. Aβ is thought to play an important role in the pathogenesis of Alzheimer's disease (AD). The...
Effects of the noradrenergic neurotoxin DSP-4 on the expression of α(1)-adrenoceptor subtypes after antidepressant treatment.
We have previously reported that chronic imipramine and electroconvulsive treatments increase the α(1A)-adrenoceptor (but not the α(1B) subtype) mRNA level and the receptor density in the rat cerebral cortex. Furthermore...
Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex.
It has been postulated that hyperactive glycogen synthase kinase-3 (GSK-3) is an important factor in the pathogenesis of depression, and that this enzyme also contributes to the mechanism of antidepressant drug action. I...