Lymphocyte-suppressing effect of simvastatin in mixed dyslipidemic patients but not impaired glucose tolerance patients.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 1
Abstract
This study compared the effect of simvastatin on lymphocyte secretory function between patients with impaired glucose tolerance (IGT) (n=30) and mixed dyslipidemia (n=29). Lipid profile, glucose metabolism markers (fasting and 2-h post-glucose challenge glucose levels, HOMA-IR and glycated hemoglobin), plasma CRP levels and the release of interleukin-2 and interferon-γ by phytohemagglutinin-stimulated T lymphocytes were determined before and after 30 and 90 days of simvastatin administration (20 mg daily). Phytohemagglutinin-stimulated T cells from both IGT and mixed dyslipidemic subjects released significantly higher amounts of both cytokines than lymphocytes of 30 dyslipidemia-free individuals with normal glucose tolerance. Despite improving the lipid profile, simvastatin produced no effects on glucose metabolism markers in either treatment groups. The drug normalized the lymphocyte cytokine release and plasma hsCRP in mixed dyslipidemic patients but not in IGT patients. Our study indicates that the presence of mixed dyslipidemia and IGT is associated with the enhanced secretory function of human lymphocytes. Simvastatin is an effective lymphocyte-suppressing agent in mixed dyslipidemic patients but not in IGT patients.
Authors and Affiliations
Robert Krysiak, Bogusław Okopień
Keywords
Related Articles
- EP ID EP91934
- DOI -
- Views 93
- Downloads 0
Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala.
Accumulating evidence supports a role for brain-derived neurotrophic factor (BDNF) in depression. However, most of these studies have been performed in animal models that have a low face validity with regard to the human...
Heme oxygenase/carbon monoxide-biliverdin pathway may be involved in the antinociceptive activity of etoricoxib, a selective COX-2 inhibitor.
The aim of this study was to assess the interaction between the heme oxygenase-1/ biliverdin/carbon monoxide (HO-1/BVD/CO) and cyclooxygenase-2 (COX-2) pathways in the writhing test. Mice were pretreated with 0.1, 1 or 1...
Effects of selective sigma receptor ligands on glucocorticoid receptor-mediated gene transcription in LMCAT cells.
It has been shown previously that sigma receptor agonists reveal potential antidepressant activity in experimental models. Moreover, some data indicate sigma receptor contribution to stress-induced responses (e.g., condi...
Role of phosphoinositide 3-kinase in ischemic postconditioning-induced attenuation of cerebral ischemia-evoked behavioral deficits in mice.
The present study has been designed to pharmacologically investigate the role of phosphoinositide 3-kinase in ischemic postconditioning-induced reversal of global cerebral ischemia and reperfusion-induced behavioral dysf...
Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy.
Cytisine, a natural plant alkaloid, has been marketed in Central and Eastern Europe for over 40 years for the clinical management of smoking cessation. Despite the fact that cytisine has been used by millions of smokers,...