Lymphocyte-suppressing effect of simvastatin in mixed dyslipidemic patients but not impaired glucose tolerance patients.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 1
Abstract
This study compared the effect of simvastatin on lymphocyte secretory function between patients with impaired glucose tolerance (IGT) (n=30) and mixed dyslipidemia (n=29). Lipid profile, glucose metabolism markers (fasting and 2-h post-glucose challenge glucose levels, HOMA-IR and glycated hemoglobin), plasma CRP levels and the release of interleukin-2 and interferon-γ by phytohemagglutinin-stimulated T lymphocytes were determined before and after 30 and 90 days of simvastatin administration (20 mg daily). Phytohemagglutinin-stimulated T cells from both IGT and mixed dyslipidemic subjects released significantly higher amounts of both cytokines than lymphocytes of 30 dyslipidemia-free individuals with normal glucose tolerance. Despite improving the lipid profile, simvastatin produced no effects on glucose metabolism markers in either treatment groups. The drug normalized the lymphocyte cytokine release and plasma hsCRP in mixed dyslipidemic patients but not in IGT patients. Our study indicates that the presence of mixed dyslipidemia and IGT is associated with the enhanced secretory function of human lymphocytes. Simvastatin is an effective lymphocyte-suppressing agent in mixed dyslipidemic patients but not in IGT patients.
Authors and Affiliations
Robert Krysiak, Bogusław Okopień
Keywords
Related Articles
- EP ID EP91934
- DOI -
- Views 101
- Downloads 0
Raloxifene similarly affects the skeletal system of male and ovariectomized female rats.
Raloxifene, a selective estrogen receptor modulator, is used for prevention and treatment of osteoporosis in postmenopausal women. Raloxifene use in male subjects is increasingly considered and a few clinical studies of...
σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation.
Background: Methamphetamine (METH) causes hyperthermia and dopaminergic neurotoxicity in the rodent striatum. METH interacts with σ receptors and σ receptor antagonists normally mitigate METH-induced hyperthermia and dop...
Endothelial dysfunction in pre-eclampsia.
The repeated demonstration of biomarkers of endothelial cell and leukocyte activation has suggested that the maternal syndrome of pre-eclampsia arises from a generalised maternal inflammatory systemic response incorporat...
Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners.
The conversion of nitric oxide (NO.) into its congeners nitrosonium (NO(+)) and nitroxyl (HNO/NO(-)) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxi...
Prophylactic effect of lithium in bipolar affective illness may be related to serotonin transporter genotype.
Serotonin transporter promoter length polymorphism (5-HTTLPR) has been implicated in the pathogenesis of mood disorders and in the therapeutic response to serotonergic drugs. In this study, the 5-HTTLPR was estimated in...