ENDOCAN: A RELIABLE BIOMARKER FOR RENAL IMPAIRMENT IN PSORIASIS VULGARIS PATIENTS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 6
Abstract
Background: Endocan may play a possible indicator for vascular endothelial related pathologies. Severe psoriasis is a risk factor for chronic kidney disease. Endocan may predict renal impairment in psoriatic patients. Aim(s): To assess risk of renal impairment in patients having psoriasis and to investigate the role of serum endocan in renal impairment in these patients. Methods: We have estimated glomerular filtration rate (eGFR) and examined serum endocan level in normotensive non-diabetic psoriasis patients (n=70) controlled to age- and gender- matched volunteers (n=60). Psoriasis area severity index (PASI) score was used to assess psoriasis severity. Results: eGFR was significantly low in psoriasis patients than controls (p = 0.02), and in sever than moderate psoriasis (p = 0.02). Endocan serum level showed a significant elevation among psoriatic cases than controls (p < 0.001), and was correlated positively with psoriasis severity (r=0.83, p < 0.001), and negatively with eGFR (r= - 0.43, P < 0.001). Severe psoriasis patients had odds ratio (OR) of 2.5 getting renal impairment compared to moderate psoriasis. The best cutoff of endocan was 507.23 pg/mL for detection of early kidney impairment in psoriasis patients (sensitivity =87.5%, specificity=82.3%, accuracy=82.9%) with area under the curve of 0.79. Psoriasis patients with high serum endocan had 2.3 OR of getting renal impairment. Conclusion: Serum endocan is associated with psoriasis severity and may be a sensitive and accurate predictive biomarker for early detection of renal impairment in psoriasis patients. Renal impairment has OR of 2.5 in severe psoriasis and of 2.3 in psoriasis patients with high endocan.
Authors and Affiliations
Azza G. A. Farag
Keywords
Related Articles
- EP ID EP637710
- DOI -
- Views 135
- Downloads 0
THE INFLUENCE OF RANBP2 MUTATION IN DEVELOPMENT OF INFLUENZA ASSOCIATED WITH ACUTE NECROTIZING ENCEPHALOPATHY IN CHILDREN. CURRENT KNOWLEDGE, AND THERAPEUTIC PERSPECTIVES
Acute necrotizing encephalopathy (ANE) is amongst the infection related brain complications in which previously healthy children develop rapidly progressive neurological disease within a week following respiratory viral...
KNOWLEDGE ABOUT RISK OF TANNING ON INCIDENCE OF SKIN CANCER AMONG SAUDI UNIVERSITY STUDENTS
Introduction: The evaluation of the knowledge gaps and attitudes towards protection measures against unnecessary sun exposure, including tanning, can act as guidance for planning of the prevention programs. This study ai...
EVALUATION OF ULTRASONOGRAPHIC AND ANTI-MÜLLERIAN HORMONE (AMH) CHANGES AS PREDICTORS FOR OVARIAN RESERVE AFTER LAPAROSCOPIC OVARIAN DRILLING VERSUS CONSERVATIVE TREATMENT FOR WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
Background: Until recently, there was no international consensus either on the definition of PCOS or on what constitutes a polycystic ovary. At a recent consensus of The European Society of Human Reproductive and Embryol...
DETERMINANTS OF UPTAKE OF TETANUS TOXOID VACCINE AMONG WOMEN OF REPRODUCTIVE AGE IN A SELECTED COMMUNITY IN FUNAKAYE LGA, GOMBE STATE, NIGERIA
Vaccinating women of reproductive age with TT is a targeted intervention which aims to reduce TT among at risk population. This study aimed to determine the level of knowledge and uptake of TT vaccine and the factors aff...
THE PROFILE OF ACUTE POISONING AND ENVENOMATIONS IN A TERTIARY HOSPITAL IN SOUTH-SOUTH NIGERIA- A 5 YEAR RETROSPECTIVE STUDY
Acute poisoning is a medical emergency. It comprises injuries in which the toxic effects manifest almost immediately. This study profiled the cases of acute poisoning and envenomations presenting to the Adult Medical Eme...