Endocrine-disrupting chemicals in polycystic ovary syndrome: an evidence-based minireview
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2012, Vol 4, Issue 3
Abstract
Polycystic ovary syndrome (PCOS) is a plurifactorial endocrine disorder, affecting 5-10% of women of reproductive age to result in hyperandrogenia, anovulation and infertility, metabolic syndrome and enhanced cardiovascular risk. Animal experiments unraveled that pre- and early postnatal exposure of female offspring to testosterone or bisphenol A (BPA), one synthetic, organic plasticizers component may induce a PCOS-like developmental pattern in adulthood. In contrast to other endocrine-disruption chemicals, information on BPA exposure in biological indicators and wildlife is scarce. On the other hand, the ability of BPA to alter ovarian steroidogenesis has been demonstrated in several cell culture models. In line with that, preliminary clinical studies demonstrated elevated serum and urinary BPA levels in PCOS patients. Nonetheless, a causative role of BPA in PCOS is still under debate and further studies on the topic are warranted.
Authors and Affiliations
Carmen Georgescu, Mihai Șuteu, Bogdan Georgescu
Keywords
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