Endothelial nitric oxide synthase (eNOS) in platelets: how is it regulated and what is it doing there?
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue
Abstract
Platelets express the endothelial form of the nitric oxide synthase (eNOS) and generate NO. However, in contrast to eNOS in endothelial cells, eNOS in platelets is largely Ca(2+)-independent and the activity is regulated by phosphorylation. Platelet-derived NO plays an important role in the regulation of platelet aggregation and secretion. Changes in the activity of platelet eNOS are responsible for the abnormal platelet activation encountered in different pathological situations (e.g. hypertension and diabetes). In this review, we will summarize the current knowledge of the role of platelet eNOS and the regulation of its activity as well as the fate of platelet-derived NO in physiological and pathological situations.
Authors and Affiliations
V Randriamboavonjy, Ingrid Fleming
Keywords
Related Articles
- EP ID EP91112
- DOI -
- Views 105
- Downloads 0
GABA(B) receptors in drug addiction.
Preclinical studies and clinical trials carried out within the past few years have provided a premise that gamma-aminobutyric acid (GABA) transmission and GABA(B) receptors play a modulatory role in the mechanism of acti...
No association of three GRIN2B polymorphisms with lithium response in bipolar patients.
We investigated three polymorphisms in the NMDA receptor 2B subunit gene (GRIN2B) as a candidate gene for lithium response involved in glutamatergic neurotransmission. One hundred five bipolar patients treated with lithi...
Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3.
Background: Acyclovir is acyclic guanosine derivative. Benzylpenicillin (PCG) is a β-lactam antibiotic. The purpose of this study was to investigate the pharmacokinetic drug-drug interaction (DDI) between PCG and acyclov...
2-Chloro-N(6)-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model.
This study examines the anticonvulsant profile of interactions between 2-chloro-N(6)-cyclopentyladenosine (CCPA, a selective adenosine A(1) receptor agonist) and four conventional antiepileptic drugs (AEDs: carbamazepine...
Impact of methylprednisolone treatment on the expression of macrophage inflammatory protein 3alpha and B lymphocyte chemoattractant in serum of multiple sclerosis patients.
In order to extend our studies designed to elucidate the mechanism of action of intravenous methylprednisolone (ivMP) in symptomatic therapy of relapses in multiple sclerosis (MS) victims, we have evaluated the expressio...