ENHANCEMENT OF ANTI-DIABETIC ACTIVITY OF 4-HYDROXYISOLEUCINE IN COMBINATION WITH NATURAL BIOAVAILABILITY ENHANCERS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: This study investigates for the first time the antidiabetic activity of 4-hydroxy isoleucine (4-OH Ile) in combination with natural bioavailability enhancers, piperine and ginger oleoresin.Methods: Alloxan induced diabetic rat model was used for studying the antidiabetic activity of 4-OH Ile in combination with natural bioavailability enhancers to study its effect on body weight, fasting blood glucose level and oral glucose tolerance test.Results: 4-OH Ile present in Trigonella foenum-graceum seeds is an amino acid that shows a significant activity in type II diabetes. Due to its glucose dependent effect and devoid of side effects, 4-OH Ile is used for management of type II diabetes. The antidiabetic activity of 4-OH Ile was found to be significantly increased in combination with piperine and ginger oleo resin. However, piperine has demonstrated better effect as compared to ginger oleoresin. Histopathological studies of pancreas were also done to further verify the effect of natural bioenhancers.Conclusion: The results of this study places piperine and ginger oleo resin as a mode of increasing activity of 4-OH Ile and thereby reducing their cost of the treatment.Â
Authors and Affiliations
Prachi Shukla, Vinod Rangari
Keywords
Related Articles
- EP ID EP578890
- DOI -
- Views 70
- Downloads 0
BIOAVAILABILITY ENHANCEMENT OF POORLY SOLUBLE RALOXIFENE BY DESIGNING INCLUSION COMPLEX WITH β–CYCLODEXTRIN
Objective: Raloxifene hydrochloride (RLX) is widely used in the treatment of osteoporosis, but due to its extensive first pass metabolism bioavailability of RLX is remaining only 2%. In addition of that being from BCS cl...
EXTRACTION, STABILITY AND SEPARATION OF ANTHOCYANINS OF <em>IXORA COCCINEA</em> LINN
Objective: In the present study, a new, simple and an efficient microwave oven extraction method was developed for maximum yield of colorant from Ixora coccinea flowers. The preliminary stability study of colorant was ca...
STATISTIC ESTIMATION OF BREAKING TABLETS OF ENALAPRIL 20 MG
Objective: The aim of this study was to evaluate the accuracy of breaking into half and quarter-tablets Enalapril 20 mg sold in the Albanian market, in dosages suitable for use in children.Methods: 100 whole tablets of E...
EVALUATION OF PHYTOCONSTITUENTS, IN VITRO ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF AGARICUS BISPORUS
Objective: The present study was aimed to investigate the phytochemicals, antimicrobial and antioxidant potential of wild edible mushroom (Agaricus bisporus). Methods: Initially, phytochemical screening was carried out t...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IMPURITIES FROM OLMESARTAN MEDOXIMIL AND HYDROCHLOROTHIAZIDE TABLET
Objective: To develop and validate stability indicating RP-HPLC gradient method for simultaneous estimation of impurities and degradation products from Olmesartan Medoximil and Hydrochlorothiazide tablet.Methods: The chr...