Enhancement of solubility and dissolution rate of Leflunomide tablets by solid dispersion technique
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
Rheumatoid arthritis is an auto immune disorder that primarily affects joints. The disease causes sewere inflammation of joints,painful joints ;also causes Inflammation around lungs and heart. It increases the risk of heart strokes . The cause of disease is yet unclear predicted to be a combination of genetic and environmental factors. The disease is diagnosed by signs and symptoms and by laboratory tests .Around 41 /1,00,000 people are diagnosed with R.A. As per statistics about 24.5 million people are affected with R.A. About 38,000 deaths are reported in the year 2013. Leflunomide is a immuno suppresive disease modifying anti rheumatic drug that show its activity by inhibiting the mitochondrial enzyme ;Di hydro rotatateDehydrogenase .hence leflunomide inhibits reproduction of rapidly dividing cells,Especially lymphocytes. Here we are preparing leflunomide solid dispersion form that enhances its soulubility and dissolution rate.
Authors and Affiliations
T. Tirumala devi, Sk Faheem Ali, M. Manisha, P. Bhanu prasad, P. Jyothi
Keywords
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- EP ID EP444248
- DOI 10.9790/3008-1401017783.
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