ENHANCEMENT OF SOLUBILITY OF POORLY SOLUBLE DRUG BY MIXED SOLVENCY CONCEPT
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
In the present study, practically water insoluble drug, meloxicam was tried to be solubilized by employing the combination of physiologically compatible menthol: thymol mixture in the form of their eutectic mixture to make its sustained release formulations. In the present study liquid solvents were not used purposely. Two solids, menthol and thymol, in the form of eutectic liquid, were employed to solubilize ethyl cellulose and drug. Menthol and thymol were removed from the formulation by heat treatment. The resultant solid mass consists of drug (meloxicam), molecularly dispersed in matrix of ethyl cellulose, which release the drug for expected prolong time.
Authors and Affiliations
P. Shailendra
Keywords
Related Articles
- EP ID EP619242
- DOI -
- Views 137
- Downloads 0
ECO-FRIENDLY APPROACH FOR LUMINESCENCE DETECTION OF BENDAMUSTINE HYDROCHLORIDE USING GOLD NANOPARTICLES IN THE PRESENCE OF ORGANIZING SOLUTION
The present approach, introduced a simple, sensitive and reliable ecofriendly spectrofluorimetric method for the determination of bendamustine hydrochloride. The described method is mainly based on the enhancement effect...
SIGNIFICANCE OF STEREOCHEMISTRY AND EUDESMIC RATIO IN CHIRAL DRUG DEVELOPMENT
Stereochemistry is the study of properties of molecules with respect to spatial arrangement of atoms or groups. A chiral molecule is a molecule which lacks an internal plane of symmetry and has a non superimposable mirro...
POTENTIAL OF ENDOPHYTIC BACTERIA FROM LIVERWORT (MARCHANTIA POLYMORPHA L.) WHICH PRODUCES ANTIBIOTICS IN STAPHILOCOCCUS AUREUS L.
Marchantia polymorpha is a type of liverwort that is often used by the Indonesian people, especially the Maninjau West Sumatra community as a source of traditional medicine in dealing with infections of the skin. This mo...
AN INTRODUCTION TO THE SYNTHETIC METHOD AND PHARAMCOLOGICAL ACITVITY OF OXADIAZOLE NUCLEUS: A REVIEW
Oxadiazole contains an oxygen atom at the 1st position and two nitrogen atom at the 3rd and 4th position which is a derivative of furan by substitution of two methylene group (=CH) with two pyridine type nitrogen atom(-N...
CHANGES IN ELECTROLYTE IONS LEVEL IN HEALTHY AND OSTEOPOROSIS WOMEN IN BASRA PROVINCE / IRAQ
Osteoporosis is the most common bone disease in humans, it is characterized by low bone mass, deterioration of bone tissue and disruption of bone architecture, compromised bone strength and an increase in the risk of fra...