ENHANCING SOLUBILITY AND DISSOLUTION OF INDOMETHACIN BY FREEZE DRYING
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Freeze dried crystals were prepared by freeze drying method. Solvent composition for freeze drying chosen were isopropyl 10 ml of alcohol: water (50:50 %) mixture. Crystallization medium used for freeze drying of indomethacin consisted of isopropyl alcohol: water in the ratio of 50:50, respectively. Spherical agglomerates were characterized by DSC, IR, XRD AND SEM. Micromeritic, mechanical property, solubility study and dissolution behavior studies were carried out. Dissolution profile of the freeze drying was compared with commercial sample and recrystallized sample. Freeze drying exhibited decreased crystallinity and improved micromeritic properties. The solubility and dissolution of the freeze drying was improved compared with commercial sample. Hence this freeze drying technique can be used for formulation of tablets of indomethacin by direct compression with directly compressible tablet excipients.
Authors and Affiliations
Mudit Dixit , Parthasarathi Kulkarni , Vamsi Naga , Lavanya Devabhaktuni , Anil Getyala
EVALUATION OF THE EXTRACTS OF LEUCAS ASPERA ON BIOCHEMICAL PROFILES IN EXPERIMENTAL MODEL OF DIABETES MELLITUS (TYPE- I) IN RATS
The study was conducted to evaluate the effect of Leucas aspera leaves on experimental diabetes mellitus (type I) in rats in terms of alterations in biochemical profiles. Thirty rats were randomly divided into six groups...
MICRONEEDLE: AS A FUTURE PROSPECTIVE TOOL
Optimization of drug delivery through human skin is important in modern therapy. With the limitations of oral drug delivery and the pain and needle phobias associated with traditional injections, drug delivery research h...
A NEW KAURANE DITERPENE FROM THE LEAVES OF CALLICARPA MACROPHYLLA VAHL.
The chloroform extract of leaves of Callicarpa macrophylla Vahl., yielded a new compound 16α-hydroxy- 17-isopropylidino-3-oxo-phyllocladane along with calliterpenone and its monoacetate.
ANTIOXIDANT ACTIVITY OF POLYGALA ROSMARINIFOLIA WIGHT& ARN WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS
Administration of ethanol extract of Polygala rosmarinifolia whole plant (100 mg/kg and 200 mg/kg body weight) to alloxan induced diabetic rats for 14 days reduced the elevated level of lipid peroxidation (LPO). The trea...
A REVIEW ON CONCEPT OF CLEANING VALIDATION IN PHARMACEUTICAL INDUSTRY
Pharmaceutical manufacturers must validate their cleaning process to ensure compliance with standard regulatory authorities. Manufacturing and cleaning equipment must be designed for effective and consistent cleaning to...