ENHANCING SOLUBILITY AND DISSOLUTION OF INDOMETHACIN BY FREEZE DRYING
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Freeze dried crystals were prepared by freeze drying method. Solvent composition for freeze drying chosen were isopropyl 10 ml of alcohol: water (50:50 %) mixture. Crystallization medium used for freeze drying of indomethacin consisted of isopropyl alcohol: water in the ratio of 50:50, respectively. Spherical agglomerates were characterized by DSC, IR, XRD AND SEM. Micromeritic, mechanical property, solubility study and dissolution behavior studies were carried out. Dissolution profile of the freeze drying was compared with commercial sample and recrystallized sample. Freeze drying exhibited decreased crystallinity and improved micromeritic properties. The solubility and dissolution of the freeze drying was improved compared with commercial sample. Hence this freeze drying technique can be used for formulation of tablets of indomethacin by direct compression with directly compressible tablet excipients.
Authors and Affiliations
Mudit Dixit , Parthasarathi Kulkarni , Vamsi Naga , Lavanya Devabhaktuni , Anil Getyala
Keywords
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