Epicardial Adipose Tissue Volume As A Marker of Atherosclerosis in Hemodialysis Population.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Backround: Epicardial adipose tissue (EAT) is a visceral fat deposit accumulated between the visceral pericardium and the myocardium. Increased epicardial adipose tissue volume is associated with development of coronary atherosclerosis. It has been reported previously that EAT volume was higher in Chronic Kidney Disease (CKD) patients on hemodialysis(HD) and peritoneal dialysis. Objective: We aimed to compare epicardial adipose tissue thickness between the CKD patients on hemodialysis and controls. Materials And Methods: Thirty patients on HD (16 males & 14 females, with a mean age of 41.97± 9.77 yrs) and thirty controls (12 males & 18 females, with a mean age of 46.93±7.27yrs) were enrolled in the study. Carotid intimal medial thickness (CIMT), Coronary artery calcification score (CACS), EAT thickness and volume were measured by appropriate imaging techniques. Results: E.A.T volume is increased in 20% (6 out of 30) of cases and 16.67% (5 out of 30) of controls. Mean E.A.T volumes in cases were 97.83 cc (±26.11) and in controls were 97.87 cc (± 28.53).No statistical significant differences noted in E.A.T volume between cases and controls. Mean CACS for cases and controls were 0.4(± 0.81) and 0.27(±0.69) respectively. No statistically significant difference noted. Mean CIMT (right) for cases and controls were 0.57mm (±0.1) and 0.57mm (±0.08) respectively. Mean CIMT (left) for cases and controls were 0.59mm (±0.13) and 0.58mm (0.10) respectively. No statistically significant difference noted. No significant association was noted between age,BMI,Triglycerides, CIMT, CACS, with EAT volume in CKD patients on hemodialysis.However there is significant positive correlation between E.A.T thickness measured using echocardiography versus CT (r=0.94, p<0.05). Conclusions The main findings of the present study are as follows: 1) E.A.T volume measured by CT is not increased in most of the CKD patients on HD. 2) No significant correlation found between E.A.T volumes with other parameters (Age, BMI, TGL, dialysis vintage, CACS, CIMT) in CKD patients on HD. 3) Significant positive correlation between E.A.T thicknesses measured using echocardiography and CT. In recent studies, a preferential association between E.A.T volume and thickness is made with CACS, CIMT. However we found no association. Our study has some limitations. 1) Sample size was relatively small. 2) Dialysis vintage was relatively short. 3)Since this is not a prospective study, we cannot draw cause and effect relation.
Authors and Affiliations
Vivek Praveen R, Suhasini B, Edwin Fernando M, Srinivasaprasad Nd
Keywords
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- EP ID EP592335
- DOI 10.9790/0853-16020696101.
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