Epidemiological Study of Molecular and Genetic Classification in Adult Diffuse Glioma
Journal Title: International Journal of Surgery & Surgical Techniques - Year 2022, Vol 6, Issue 2
Abstract
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in lowgrade and high-grade gliomas. However, the diagnostic criteria, in particular for gliomas, are highly various. The aim of our study was to establish genetic profiles for mutation and calcification of diffuse gliomas and to evaluate their predictive factors. Methods: We estimate the different clinical and molecular characterization between IDH1, IDH2 mutant gliomas, p53, ATRX and 1p19q. In addition, whole-transcriptome sequencing and DNA extraction data were used to evaluate the distribution of genetic changes in IDH1 and IDH2 mutant gliomas in a Iranian high grade glioma. Results: Between 2016-2019, among 53 gliomas in our study, 29 cases (54.7% %) harbored an IDH1,2 mutation, 21 cases (39.6 %) harbored an p53 mutation and 19 cases (35.8 %) harbored an ATRX. In addition, 1p19q co-deletion mutation was found in 7 cases (12.2%). We found that IDH1 and IDH2 are mutually entirely in gliomas. There was no significant relation between histopathology, tumor location and clinical finding with diagnosed mutations. Conclusion: Our study discloses an associated distinction between IDH1 and IDH2 mutant gliomas nearly in half of patients, followed by p53. These mutations should be reviewed separately because their differences could have indication for the diagnosis and treatment of IDH1/2 mutant gliomas.
Authors and Affiliations
Alenabi A, Farajirad M*, Mahmoudi A, Torabi S, and Farajirad E
Keywords
Related Articles
- EP ID EP747457
- DOI 10.23880/ijsst-16000171
- Views 2
- Downloads 0
Epidemiological Study of Molecular and Genetic Classification in Adult Diffuse Glioma
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in lowgrade and high-grade gliomas. However, the diagnostic criteria, in particular for gliomas, are highly va...
Irritational Pyogenic Granuloma - A Case Report
Gingival overgrowth, results due to increase in the number of cells or cell size. Pyogenic granuloma (PG) a relatively common gingival tumour like over growth, occurs as an exuberant tissue response to localized irritat...
Subplatysmal Endoscopic Guided Endotracheal Tube Cuff Inflation Facilitates Working Space Creation in Transoral Endoscopic Thyroidectomy, A Novel Technique
Transoral endoscopic thyroidectomy is a natural orifice thyroid surgery, minimally invasive and completely scar free. However, the working space of this procedure is relatively small and is also difficult to create comp...
Gastric Tumor Perforation Repair with Falciform Ligament
The rate of perforation in gastric tumors has been reported to be between 0.5 and 3.9%. Because the tumor is not diagnosed at the moment, or the tumor's stage is unknown, repairing the perforation site is recommended ra...
Potential Effect of Colchicine in the Prevention of Acute Respiratory Distress Syndrome (ARDS) In Patients with Covid-19 Infection
This work presents the theoretical basis for the use of Colchicine in the prevention of Acute Respiratory Distress Syndrome (ARDS) associated with COVID-19 infection. Several reports show that the common final event tha...