Epigenetic Regulation of Breast and Prostate Cancer
Journal Title: Journal of Clinical and Medical Research - Year 2020, Vol 2, Issue 2
Abstract
Aim: Epigenetic investigates gene expression modifications not due to DNA sequence alterations. Gene expression modifications appear with packing of DNA with variety of chromatine structures. Materials and Methods: The most studied forms of epigenetic phenomenon are DNA methylation and histone modifications. These pathways are connected with each other and reversible. DNMT family members which take place at epigenetic mechanism DNMT1, 3a also shown at breast cancer MCF-7 and prostate cancer brain-metastasis- DU145 with RT- PCR and western methods. Results: Histone modification which close the gene expression is histone deacetylation had been reversed by Trichostatin A(TSA). It is reported that inhibition of methylation and deacetylation in a serial way result with succesful gene activation, performed with5-aza-2'- deoksitidin and TSA incubation at the project. Conclusion: In the recent years, epigenetic base had been shown for many diseases that research and development for epigenetic disorders won successful treatment cases. Preclinic and clinic levels of candidate drugs are on the way.
Authors and Affiliations
Aysegul Kaymak-Aras1 and Ceren Gonen-Korkmaz2*
Keywords
Related Articles
- EP ID EP708392
- DOI https://doi.org/10.37191/Mapsci-2582-4333-2(2)-025
- Views 68
- Downloads 0
prednisolone with artesunate effect on henoch schonlein purpura with malaria condition
Henoch Schonlein Purpura (HSP) is a common form of systemic vasculitis which is mostly seen in children and rarely in adults. It is clinically characterized by the symptoms of palpable purpura, joint pains, abdominal pai...
Crossroad of Molecular Networks and Disease Treatment
Various molecular networks including both canonical and non-canonical pathways are activated in cancer. It has some rationales to target the molecular network pathways to treat cancer, considering that the pathway regula...
International Reactions to COVID-19
The recent outbreak of the 2019 novel coronavirus in China, which was tentatively named 2019-nCoV, and now officially declared as COVID-19 by the World Health Organization (WHO), [1] has caused a lot of panic around the...
Changes in Visual Parameters in an Adult Amblyope With Vision Therapy
Amblyopia is a common neurodevelopmental visual disorder that results in reduced contrast, motor perception, and excessive crowding along with impaired visual acuity. Literature suggested this disorder can be treated wit...
Corona Virus (COVID-19) Awareness Assessment-A Survey Study amongst the Indian Population
Aim: The aim of this survey study was to assess the level of awareness amongst Indian population regarding the COVID-19. Method: A survey was conducted amongst 745 individuals to assess their level of awareness regard...