prednisolone with artesunate effect on henoch schonlein purpura with malaria condition
Journal Title: Journal of Clinical and Medical Research - Year 2019, Vol 1, Issue 3
Abstract
Henoch Schonlein Purpura (HSP) is a common form of systemic vasculitis which is mostly seen in children and rarely in adults. It is clinically characterized by the symptoms of palpable purpura, joint pains, abdominal pain, nephritis, bowel perforation rarely CNS involved. HSP has incidence of 15 cases in 1,00,000 children per year. The etiology of the disease remains unclear but antigens such as infective agents, vaccination, drugs, insects and foods can trigger this autoimmune disease. The hormonal changes such as usage of oral contraceptives, during menstrual cycle, during pregnancy & hormones like dehydro-epiandrosterone, testosterone and estrogen also triggers autoimmune disease. Here we report a case of female patient affected with HSP which is triggered due to hormonal changes. A 12 years female patient admitted in hospital with complaints of restricting to walk, swelling of legs since 2 days, petechial rash, pain over arm and forearm, burning sensation in legs, rash started over ankle region which started spreading since 1 day. Then after admitting in hospital she was suffered with on and off fever and was diagnosed as malaria. On examination of past history she had hypothyroidism 1 year back and under medication for 6 months. She attained puberty but with abnormal menstrual cycle for 3 months. Based on these conditions it was finally diagnosed as HSP with malaria. The condition was treated with corticosteroids and antimalarial drugs. During the treatment we observed adverse effects- swelling in scalp and peripheral neuropathy due to prednisolone and increase in rashes due to artesunate.
Authors and Affiliations
Tejaswi Chittem, Pavani Thota*, Ravi Chander Thatipelli and Sayed Fermiza Begum
Keywords
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- EP ID EP708374
- DOI https://doi.org/10.37191/Mapsci-2582-4333-1(3)-018
- Views 109
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