The Therapeutic Mechanism of COVID19
Journal Title: Journal of Clinical and Medical Research - Year 2020, Vol 2, Issue 5
Abstract
The coronavirus disease-19 (COVID-19) is circulating all over the world. To understand and find a way of the COVID-19 treatment, the therapeutic mechanism of COVID-19 is focused on in this Editorial. The pathogenesis of COVID-19 includes the molecular networks such as the binding of the membrane proteins, signaling pathways and RNA replication. The mechanism of infection and targets of the therapeutics are explored and summarized. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a new type of the coronavirus causing COVID-19, infects the cells via the binding of the membrane proteins of human cells, and is internalized by the cells. The viral genome is replicated by RNA-dependent RNA polymerase (RdRp), followed by the packaging and releasing the viral particles. These steps can be main targets for the therapeutics of COVID-19. On the other hand, over-driven immune responses, so-called “cytokine storm” is one of the main causes of the severe COVID-19. These immune responses are also important targets for the therapeutics of severe COVID-19. In this Editorial, some of the insights in the rapidly increasing abundant research reports on COVID-19 are introduced for the future acceleration of the therapeutic development.
Authors and Affiliations
Shihori Tanabe
Keywords
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- EP ID EP708406
- DOI https://doi.org/10.37191/Mapsci-2582-4333-2(5)-048
- Views 42
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