Infiltration of the Mascagni Node is a Strong Prognostic Factor for Gall Bladder Cancer Discovered in Resected Specimen
Journal Title: Journal of Clinical and Medical Research - Year 2020, Vol 2, Issue 4
Abstract
Introduction: The infiltrative node is a strong prognostic indicator of survival in gallbladder cancer. The profile of the Mascagni ganglion (Ganglion of the neck of the gallbladder) has never been studied and taken into account for the form of histological discovery. The purpose of this retrospective study is to assess the impact of the Mascagni lymph node profile (GGM) and the prediction of the presence of residual tumor tissue after a histological discovery of gallbladder cancer. Material and method: Forty-one patients were collected. Group A (No infiltrated Mascagni node) is made up of 15 patients while group B (infiltrated Mascagni node) is made up of 26 patients. Complementary secondary surgery was retained in 27 patients (65.8%) who underwent complimentary radical surgery in 16 (39%) of them and palliative surgery for 10 others (24,4%). Sixteen patients (39%) did not have secondary surgery. The mean time to reopen was 93.9 (48-166) in group A and 85.6 (21-230) days (p=0.5). Only 2 patients (13.3%) of group A had a residual tumor (carcinomatosis) and 100% of patients of group B presented this residual tumor with or without second surgery (p<0.001). Result: No patient of group A had infiltrated lymph node even after second surgery while 92.3% (24/26) of group B had finally infiltrated lymph node (results of two interventions) (p<0.001). Survival is significantly higher in-group A than in-group B. with global five-year survival reaching 46.6% vs only 03.8%. Free survival is significantly higher for group A than group B (73.3% (11/15) vs 03.8% (3/26). The survival is also significantly higher for both cholecystectomy alone and radical secondary surgery with 62.5% (05/08) vs 00% (00/16) (p < 0.05) and 85.60% (06/07) vs 30% (03/10) respectively (p<0.01). Conclusion: GGM is a strong prognostic factor for gall bladder cancer discovered on the resected specimens. It must be noted systematically on the histological reports and be taken into account before the secondary radical surgery.
Authors and Affiliations
Salah Berkane*, Salim Belkherchi, Youcef Mahmoudi, Mustapha Kheder and Chemssedine Benkhelat
Keywords
Related Articles
- EP ID EP708399
- DOI https://doi.org/10.37191/Mapsci-2582-4333-2(4)-044
- Views 55
- Downloads 0
A Point of Care Lateral Flow Assay for Rapid and Colorimetric Detection of Interleukin 6 and Perspectives in Bedside Diagnostics
Interleukin-6 (IL-6) is a multifunctional cytokine and high bloodstream levels of which have been associated with severe inflammatory diseases, such as dengue fever, sepsis, various cancers, and visceral leishmaniasis (V...
Effect of Fluoride Mouthwash in Iranian Schools: Treatment or Exacerbation of the Disease
Dental and oral health is an important part that plays a significant role in the quality of life of people in our society, especially children, but due to insufficient attention, tooth decay in the world is increasing ev...
Exploring the Role of Remote Ischemic Preconditioning in Long Term Cognitive Impairment after Global IschemiaReperfusion-Induced Vascular Dementia in Mice
Aim: The aim of the present study is to explore the neuroprotective effects of remote ischemic preconditioning in long term cognitive impairment after global cerebral ischemia induced-vascular dementia in mice. Materi...
Demonstration of Specific Marker Proteins, Determining Spermatozoa Fertility, and of Proteins, Common for Sperm and Other Cellular Types (Stem/Progenitor, Malignant and Differentiated Normal Cells)
The condensation of nuclear chromatin in mature differentiated male germ cells is an important morphological marker about their fertilization capability or male fertility, respectively. Spermatozoa with decondensed chrom...
Pulmonary Tuberculosis Mimicking Lung Cancer and Metastasis Radiologically- A Case Report
Tuberculosis (TB) is known to mimic several clinical conditions, especially malignancy. Pulmonary TB can present with pulmonary infiltration with or without mediastinal lymphadenopathy. TB often gets misdiagnosed in the...