Epigenetics - A Window Towards Personalized Periodontal Therapy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 6
Abstract
Periodontitis is characterized by infection and inflammation of tooth supporting tissues. Even though pathogenic microorganisms are the primary etiological factor, the progression is modified by genetic factors of the individual. Many environmental factors such as smoking, inflammation, malnutrition are identified as risk factors. Epigenetic modifications occur in response to environmental changes which can affect gene expression and is not mediated by mutations. Recent research using genome wide analysis highlights that genetic variations are associated with an increased risk of periodontitis. Epigenetic drugs may provide an opportunity to develop tailor made therapies and enhance the effects of combination therapy.
Authors and Affiliations
Dr. Seba Abraham, Dr. Greeshma Saseendran, Dr. Ambili R
Keywords
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- EP ID EP600319
- DOI 10.9790/0853-1606013337.
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