Estimation and Comparison of Serum Beta 2 Microglobulin Level Among Patients with Oral Leukoplakia, Oral Submucous Fibrosis, Oral Squamous Cell Carcinoma and Controls – An Observational Study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 5
Abstract
Background: The second most common cause of death in India is oral cancer, which develops from potentially malignant disorders like oral leukoplakia and oral submucous fibrosis. There is a need for early detection of potentially malignant disorders and tumor marker serum beta 2 microglobulin looks promising for oral leukoplakia. Aim: The study was conducted with the aim to estimate the serum β2 Microglobulin levels among patients with oral leukoplakia, oral submucous fibrosis, oral squamous cell carcinoma and compare with controls. Materials and Method: A total of 100 subjects with 25 in four groups were selected. Group I comprised of clinically and histopathologically confirmed cases of oral leukoplakia. Group II comprised of clinically diagnosed cases of oral submucous fibrosis. Group III is clinically and histopathologically diagnosed cases of oral squamous cell carcinoma and group IV is control group. Serum β2M levels were measured by chemiluminescent method using Immulite 1000 (Siemens). Kruskall-Wallis one way ANOVA was done to compare among 4 groups and Mann-Whitney U test was used to compare between groups. The p-value of less than 0.001 was considered statistically significant. Results and conclusion: Mean serum β2M level in oral leukoplakia group is 2597 ± 148.6 ng/mL, oral submucous fibrosis group is 2187.68 ± 678.6 ng/mL, oral squamous cell carcinoma group is 3166.04 ± 357.7 ng/mL and control is 1542.60 ± 337.7 ng/mL. Statistically significant increase in mean serum β2M level was observed in oral leukoplakia and oral squamous carcinoma patients compared to controls. However, increase in serum β2M levels was not statistically significant in oral submucous fibrosis. The present study confirmed that serum β2M can be used as a promising tumor marker for oral leukoplakia and oral squamous cell carcinoma, as other condition causing elevation of serum beta 2 microglobulin were excluded.
Authors and Affiliations
Dr. John Baliah
Keywords
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