Estimation of Lactate Dehydrogenase Activity in cerebrospinal fluid in different types of meningitis
Journal Title: International journal of Advanced Biological and Biomedical Research - Year 2017, Vol 6, Issue 1
Abstract
Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein and sugar in CSF of different types of meningitis. Methods: A total of 160 cases, aged between 1 month and 60 years, including patients with bacterial meningitis (n=50), pyogenic meningitis (n=46), viral meningitis (n=24) and a control group (n=40), were analyzed on the basis of data from the initial clinical examinations. Results: Significant increase in LDH level (P<0.001) were observed in the test group when compared to the control group. The LDH activity was significantly elevated in the CSF and serum (p < 0.001) in cases of pyogenic (PM) as well as tuberculosis meningitis (TBM). Bacterial meningitis is more common than non bacterial meningitis. The enzymatic activity of LDH although significantly raised in PM compared to TBM but there was no cutoff level to differentiate them. The LDH level did rise quite significantly in pyogenic meningitis.
Authors and Affiliations
Ranbeer kumar Singh| Department of Microbiology Narayan Medical College and Hospital, Jamuhar, Sasaram, Bihar, Farhan Usmani| Department of Biochemistry, Patna medical college and Hospital, Patna, India, Syed Shahzadul Haque| Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India, Md. Tanweeruddin| Department of Anaesthesiology and Critical Care, ECR, Danapur, Baban Kumar Singh| Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
Keywords
Related Articles
- EP ID EP13579
- DOI 10.18869/IJABBR.2017.412
- Views 415
- Downloads 34
Synthesis,Characterization, Biological Evaluation and anti corrosion activity of some new bis-piperidone Derivatives
Aseries of piperidine derivatives was synthesis by the reaction between substituted benzaldhyde ,pentanone-3,and ammonium acetate by refluxining for 1-2 hr in ethanol and the derivatives refluxed with (4,4'-Diaminodiph...
Review on Passive Defense Legal Requirements in Territorial Planning
Nowadays, given different definitions and conceptions on development, territorial planning lends to for various economic, social and geographical aspects, however its defensive and security perspectives have been taken i...
Water quality assessment of the Zarivar Lake using physico-chemical parameters and NSF- WQI indicator, Kurdistan Province-Iran
The Zarivar Lake a freshwater lake in west of Kurdistan Province is home for large number of native plant and animal species therefore water quality and health of the lake are vital for conservation of these species. T...
An Investigation of Energy Use Efficiency and CO2 Emissions for Grape Production in Zanjan Province of Iran
Objective: The aims of this study were to determine energy efficiency and CO2 use pattern of grape production in Zanjan province, Iran by a non-parametric method of data envelopment analysis (DEA). Methods: Initial dat...
An experimental study of the systemic alteration of nitroimidazoles in the middle stage of embryonic development
Nitroimidazole compounds have been traditionally used in the veterinary and human medicine, but their uses are sometimes associated with some side effects. Toxicopathological effects of nitroimidazoles have always been...