Estimation of Thyroid Gland and Pancreatic Functioning in Patients with Chronic Hepatitis B and C Combined with Autoimmune Thyroiditis and without it
Journal Title: Міжнародний ендокринологічний журнал - Year 2012, Vol 42, Issue 2
Abstract
Chronic viral hepatitis is one of the most urgent problems of the healthcare. Viral hepatitis is not restricted with liver damage; they are like systemic disease proceeding with obligate development of extrahepatic manifestations. Among endocrine manifestations the most common are autoimmune thyroiditis and diabetes mellitus. The aim of the current study is the comparative evaluation of functional status of thyroid and pancreas in patients with chronic viral hepatitis combined with autoimmune thyroiditis and without it. 69 patients were observed in 3 clinical groups: I group — patients with autoimmune thyroiditis, II group — autoimmune thyroiditis with chronic viral hepatitis, III group — with chronic viral hepatitis. According to the study results the following was elicited: accurate increase in antithyroid peroxidase antibodies level in patients with autoimmune thyroiditis with chronic viral hepatitis, which could be caused by the presence of autoimmune inflammatory process in thyroid against moderate activity of chronic viral liver disease; statistically significant increase in antithyroid peroxidase antibodies level in patients with chronic viral hepatitis, likely connected with autoimmune inflammatory process in thyroid caused by HBV and HCV viral infections; accurate reduction of C-peptide and insulin levels in autoimmune thyroiditis patients with and without chronic viral hepatitis, which might be a predictor of probable diabetes mellitus associated with chronic hepatitis development.
Authors and Affiliations
Kh. T. Rustamova, M. P. Mirakhmedova, Kh. N. Abdullayeva
Keywords
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