“ESTIMATION OF VITAMIN B12 LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON METFORMIN: A HOSPITAL BASED STUDY”
Journal Title: GJRA-Global Journal For Research Analysis - Year 2018, Vol 7, Issue 11
Abstract
BACKGROUND: Metformin is considered as the rst-line antidiabetic agent in the treatment of type 2 diabetes mellitus (T2DM) due to its effect on glucose and lipid metabolism. The mechanism of action of Metformin in improving hyperglycemia involves in improving the signaling of insulin together with suppressing hepatic gluconeogenesis. METHODS: 45 patients with type-2 diabetic patients on metformin therapy with an age ranged from 30 to 65 years along with 45 healthy controls were recruited from the General Medicine Department of HMCH, Rourkela according to inclusion and exclusion criteria. RESULTS: The mean age and BMI of both the cases and controls were 48.62 ± 7.94 and 43.52 ± 5.24; 28.04 ± 4.34 and 26.54 ± 3.32 respectively. Mean serum vitamin B12 levels in the case group was 217.45±86.32 and in control was 370.08±91.6and the difference was statistically signicant. CONCLUSION: Metformin which is rst line oral hypoglycemic agent as recommended by ADA is signicantly associated with decrease in vitamin B12. There is moderate correlation between the markers of B12 status and levels of fasting blood sugar as well as HbA1C. There is a signicant correlation between insulin and C-peptide with the markers of vitamin B12 status.
Authors and Affiliations
Dr Prafulla Kumar Mishra, Dr Brijesh Mukherjee
Keywords
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