Ethnopharmacological study of plants used to treat malaria, in traditional medicine, by Bete Populations of Issia (Côte d’Ivoire)
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
Malaria is the major tropical pathology in developing countries and man used the medicinal properties of many plants to fight this disease. During an ethnopharmacological survey in 13 villages of Issia, a Department of Côte-d’Ivoire, 37 traditional healers were interviewed. They used 32 plants to develop 32 monospecific receipts to treat malaria. Leaves and stem barks are more requested. The preparation of the medicamentous receipts utilizes mainly decoctions (81.81 %). The majority of the remedies are employed by oral way, particularly out of drink (93.93 %). For each plant, 100 g of powdered material were extracted three times in ethanol. The combined extracts were filtered and concentrated to dryness using a rotary evaporator. The ethanolic extracts were tested against chloroquine-resistant FcB1/ Colombia strain of Plasmodium falciparum. Extracts were prepared in DMSO at a concentration of 10 mg/ml and serially diluted with culture medium before to be added to asynchronous parasite cultures (1% antiparasitemia and 1% final hematocrite) in 96-well microplates. The growth inhibition for each extract concentration was determined by comparison of the radioactivity incorpored into the treated culture with that in the control culture maintained on the plate.The results of plants extracts evaluation showed that fourteen plants (43.75 %) had good antiplasmodial activity in vitro with IC50 values ranging from 2.3 to 14.1 µg/ml. The ethnopharmacological informations and the results in vitro of antiplasmodial activities of the selected plants indicate the rightfulness of the traditional use of the studied plants as antipaludics.
Authors and Affiliations
N. Zirihi Guédé , K. N'guessan , T. Etien Dibié , P. Grellier
Keywords
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