Etiological spectrum of adults presesenting with malabsorption: Experience at a tertiary centre
Journal Title: IP Archives of Cytology and Histopathology Research - Year 2018, Vol 3, Issue 1
Abstract
Introduction Malabsorption occurs due to different causes and the clinical presentation varies with the underling etiology Very few studies have been done to determine the etiological spectrum of malabsorption in northern IndiaAim To assess the etiology in patients presenting with malabsorption and to study clinical haematological biochemical serological endoscopic and histological features of these patientsMaterials and Methods Clinical assessment of 91 cases presenting with malabsorption complains in the gastro OPD was done along with vitamin B12 and fecal fat estimation Relevant haematological serological investigations endoscopy was done Duodenal biopsy was taken Data was obtained and analysed All patients clinically presenting with malabsorption were included in the study The patients excluded were those who refused for endoscopy or participation in the studyResults The most common causes of malabsorption were nonspecific duodenitis428 celiac disease CD187 tropical sprue TS 88 giardiasis33 eosinophilic enteritis 22 lymphangiectasia11 abetalipoproteinemia11 and 22 cases were normal histologically The principal features differentiating celiac disease and tropical sprue were also noted Patients with CD more often had anemia scalloping of folds on endoscopy moderate or severe villous atrophy and increased intraepithelial lymphocytes in comparison to patients with TSConclusion CD is commoner than TS Though histology is gold standard for the diagnosis of CD TS and other intestinal mucosal diseases correlation of histological findings with clinical hematological endoscopic and serological findings is important as subtle histological changes may be missed depriving the patient of proper treatmentKeywordsnbspCeliac disease Diarrhea Malabsorption Tropical sprue Villous atrophy IELs
Authors and Affiliations
Anshu Singh, Vatsala Misra, Anu Singh, Kachnar Varma, SP Misra
Keywords
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- EP ID EP490538
- DOI 10.18231/2456-9267.2018.0007
- Views 89
- Downloads 0
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