Evaluate the vitality of Dermatophagoides pteronyssinus allergen through in vivo and in vitro tests
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2018, Vol 9, Issue 28
Abstract
Introduction. A series of studies by international authors have shown that the house dust mites, especially D.pteronyssinus, is the cause of allergic rhinitis. Vietnam is a tropical monsoon climate, sunny, hot, humid. That is a favorable condition for Dermatophagoides pteronyssinus developed. Objective. This study aimed to evaluate the activity of Dermatophagoides pteronyssinus allergens via in vivo and in vitro. Method. Seventy-eight patients with allergic rhinitis visited the Clinical Immunology Clinic at Hai Phong Medical University. Thirty healthy volunteers who had no chronic illness, no history of allergy were included. Results. The rate of skin prick-test being positive for D.pt allergens made in Vietnam was 67.9% compared to control group 6.7%, France's D.pt allergens was 65.4% and 6.7%, and China’s D.pt allergen was 70.5% and 6.7%. This difference was statistically significant (P<0.01). The nasal stimulation test for 78 patients with allergic rhinitis and 30 healthy controls: the percentage of patients allergic with Vietnam’s D.pt was 66.7%, France's D.pt allergen was 64.1%, and Chinese D.pt allergen was 69.2%. The rate of white blood cell lysis and mastocyst degradation rate in allergic rhinitis group induced by D.pteronysinus were 100%. Conclusion. The immune activity of Dermatophagoides pteronyssinus made in Vietnam through in vivo and in vitro tests is equivalent to the international standard allergens.
Authors and Affiliations
Thuc PHAM VAN
Keywords
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- EP ID EP570336
- DOI 10.12699/jfvpulm.9.28.2018.41
- Views 73
- Downloads 0
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