Increase of alveolar nitric oxide concentration in patients with sleep apnea and its correlation with nocturnal hypoxemia and sleep apnea severity
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2018, Vol 9, Issue 29
Abstract
Background. Obstructive sleep apnea syndrome (OSAS) is characterized by periodic obstruction of pharynx, leading to respiratory airways inflammation and endothelial dysfunction. The concentration of exhaled NO has been used to evaluate and monitor both phenomena. Method. Prospective study on 116 patients with suspected OSAS symptoms. Respiratory function, polysomnography, and exhaled NO measured had been done for each patient. Patients with apnea-hyponea index (AHI) <5/hour were included in control group. Results. Alveolar NO concentration (CANO) was significantly increased in patients with OSAS (N=84; P<0,001) in comparison with control subjects (N=32). There were no significant differences between two groups for bronchial NO concentration (J’awNO) and total NO concentration (FENO) (P>0,05). In OSAS group, there were the linear correlations between CANO and AHI (R=0.643; P<0,001), CANO and the ratio of sleep time with SpO2 <90% in total sleep time (TS-90%) (R=0.584; P<0,001). Conclusion. The result shows that CANO is correlated with the severity of AHI and noctural hypoxemia in patients with obstructive sleep apnea syndrome.
Authors and Affiliations
Chau LUU MINH
Keywords
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- EP ID EP570770
- DOI 10.12699/jfvpulm.9.29.2018.32
- Views 54
- Downloads 0
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