Study of correlation between exhaled NO measured by portable device and bronchial hyperresponsiveness in subjects with chronic cough
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2018, Vol 9, Issue 27
Abstract
Introduction. Measurement of nitric oxide (NO) in exhaled breath may help to diagnose asthmatic patients have nocturnal chronic cough as a main symptom. However, the correlation between the level of fractional exhaled NO (FENO) and bronchial hyperresponsiveness (BHR) in asthma has not been clearly demonstrated. Objective. This study aimed to evaluate the level of FENO and BHR in subjects with chronic cough, the correlation between the level of FENO and concentration of PD20 – methacholine, and the cut-off of FENO for diagnosis of BHR. Method. Subjects with chronic cough were included in this study. They underwent FENO measurements, methacholine challenge and lung functional testing. Results. There were 32 healthy control subjects and 67 subjects with chronic cough were included in this study. The mean age and male - female ratio were not different between two groups (43±7 vs 42±6 years; 1.4 vs 1.3). The level of FENO in subjects with chronic cough was significant higher than that in control subjects (37±12 vs 15±8 ppb; P <0.01). The percentage of subjects had the positive BHR in subjects with chronic cough was significantly higher control subjects (55.2 vs 3.1 %; P<0.001). In subjects with BHR (+), FENO level was tightly correlated with log PD20 (R = -0.83; P<0.001). The cut-off of FENO level for diagnosis of BHR (+) is >36 ppb with the highest sensitivity and specificity (>80% and >75%). Conclusion. The measurement of FENO with portable device is a useful tool to diagnose subjects with bronchial hyperresponsiveness, especially for subjects with chronic cough.
Authors and Affiliations
Sy DUONG-QUY
Keywords
Related Articles
- EP ID EP570003
- DOI 10.12699/jfvpulm.9.27.2018.11
- Views 91
- Downloads 0
Laboratory techniques for diagnosis of obstructive sleep apnea (OSA) in children
Sleep apnea in children has been widely recognized in the past few decades, which is a significant cause of childhood illness and accounts for 1% to 5%. Obstructive sleep apnea (OSA) can lead to serious complications if...
Prevalence of bronchial asthma symptoms associated with allergic rhinitis manifestations in Parakou, Benin
Introduction. The prevalence of asthma symptoms in the general population is little known in limited resources countries. The overall objective of this study was to determine this prevalence in Parakou, the 3rd city in B...
Knowledge and attitudes of the students of the Niamey Faculty of Health Sciences on tobacco
During these last 10 years we note a growing consumption of the tobacco especially that of chicha by the young Nigeriens. This pushed us to do this work. It was a prospective cross-sectional study over 20 months (January...
Evaluation of the cardiovascular status of pulmonary tu-berculosis patients with positive smear new cases in both phthisiology departments of the two national hospitals of Niamey
Background. Heart attacks among pulmonary tuberculosis with positive microscopy (TPM +) are common , hence the need to carry out this study. Objective. To evaluate the cardiovascular status of patients TPM + new cases i...
The change of ventilatory function in patients with CO2 inflating in peritoneal cavity for abdominal endoscopic anesthesia surgery
Objective. This study aimed to describe the change of PetC02, peak and Vt in patients with abdominal endoscopic anesthesia surgery when CO2 inflating into peritoneal cavity at Military Central Hospital. Methods. It was...