Evaluating the informativity and specificity of diagnostic criteria for primary screening for acromegaly
Journal Title: Міжнародний ендокринологічний журнал - Year 2019, Vol 15, Issue 4
Abstract
Background. The most effective method for early diagnosis of any disease, and especially such rare as acromegaly, is considered to be population screening in high-risk groups, the introduction of which in Ukraine requires the development of methodological approaches and economic substantiation. The purpose of the study: based on a comparative analysis, to determine the informativity and specificity of questions that will be included in the questionnaire of primary screening for acromegaly. Materials and methods. The survey was conducted in two groups of people: group 1 — patients with diagnosis of acromegaly verified in the neuroendocrinology center of State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine” (n = 123); group 2 (n = 550) — persons from the risk group, namely, those who came to an outpatient visit to a general practitioner, therapist, cardiologist, endocrinologist for various reasons and in the presence of somatic and/or endocrine pathology. The evaluation of the obtained data was carried out by the analysis of variance using the software complex SPSS 19.0 (IBM Corp., Armonk, NY, USA). Results. The first set of questions in the developed questionnaire is the evaluation of phenotypic characteristics, that is, the patient’s assessment of changes in his/her appearance. The second set of questions is the determination of complaints by patients that can be a sign of the presence of a pathological process in the central nervous system and pituitary gland. Based on the comparative analysis, in the final version, the questionnaire had 11 questions, which reflect the most significant signs and clinical manifestations of permanent excessive growth hormone. The questionnaire is intended for interviewing individuals at risk in order to carry out opportunistic screening for acromegaly. Conclusions. The proposed method for evaluating the significance of clinical signs of acromegaly allows us to determine with a high degree of probability the final questions for the screening questionnaire.
Authors and Affiliations
O. O. Khyzhnyak, M. R. Mykytyuk, R. S. Nikolaiev, N. Ye. Barabash, K. H. Manska
Keywords
Related Articles
- EP ID EP630810
- DOI 10.22141/2224-0721.15.4.2019.174816
- Views 77
- Downloads 0
Adiponectin in Patients with Type 2 Diabetes Mellitus with Normal Body Weight
It was found that in patients with type 2 diabetes mellitus with normal body weight, average level of adiponectin (AN) in the blood plasma, in contrast to patients with overweight and obesity, is within reference range....
Insulin-like growth factor-1 and chronic kidney disease in patients with type 2 diabetes mellitus
Background. Diabetes mellitus (DM) and chronic kidney disease (CKD) are two major medical and socio-economic problems of recent years that the world community has faced in the context of a chronic disease pandemic. CKH l...
Peculiarities of changes in anticoagulant and coagulant activity in patients with coronary artery disease combined with type 2 diabetes mellitus
Background. Determining the features of regulatory mechanisms of plasma hemostasis in patients with coronary artery disease (CAD) and concomitant type 2 diabetes mellitus (DM) is of theoretical and practical interest, as...
Safety and Clinical Efficiency of Using Combined Preparation of Metformin Extended-Release and Glimepiride
The article explains the early use of a combination of glucose-lowering drugs that act on different stages of pathogenesis of diabetes mellitus (DM) type 2. The aim of the study was to evaluate changes in the indicator o...
New Opportunities in Prevention of Diabetes Mellitus Type 2
.