Evaluating the Prognostic Significance of Bone Marrow Megakaryocyte Count in Patients with Idiopathic Thrombocytopenic Purpura
Journal Title: Iranian Journal of Blood and Cancer - Year 2012, Vol 4, Issue 3
Abstract
Background: Previous studies about the relationship between bone marrow megakaryocyte count and the chronicity of ITP has yielded paradoxical results. The aim of the present study was to investigate any relationship between the megakaryocyte count in the bone marrow and the chronicity of ITP. Materials and Methods: This study was performed to compare the primary bone marrow aspiration megakaryocyte count, obtained early upon the diagnosis of ITP, between chronic ITP (case) and acute ITP (control) groups among patients aged less than 15 years old, at Mofid Hospital, Tehran and Amir-Kabir Hospital, Arak. Data collected was analyzed using SPSS version 18. The project was approved by local Ethics committee and written informed consent was obtained from all parents. Results: Three hundred and seven patients with ITP including 212 patients with acute ITP (69.1 %) and 95 patients with chronic ITP (30.9 %) participated in the study. The bone marrow megakaryocyte count was increased in 263 patients (85.7 %), decreased in 7 patients (2.3 %), and normal in 37 patients (12.1%). Among 212 patients with acute ITP, the bone marrow megakaryocyte count was increased in 182 patients (85.8 %), decreased in 5 patients (2.4%), and normal in 25 patients (11.8 %). Among 95 patients with chronic ITP, the bone marrow megakaryocyte count was increased in 81 patients (85.3 %), decreased in 2 patients (2.1 %), and normal in 12 patients (12.6%). There was no statistically significant difference between two groups regarding the megakaryocyte count. Conclusion: Based on our findings it seems that the variant of bone marrow megakaryocyte count is not related to the chronicity among patients with ITP.
Authors and Affiliations
A. Eghbali, M. Arzaninan, R. Jadidi
Keywords
Related Articles
- EP ID EP368582
- DOI -
- Views 45
- Downloads 0
Platelet Satellitism in a Three and Half Year Old Girl with Hemolytic Anemia and Normal Platelet Count
Platelet adherence surrounding leucocytes in a rosette formation or platelet satellitism is a rare phenomenon. This finding has been observed almost exclusively in Ethylenediaminetetraacetic acid treated blood at room te...
Flow Cytometric Measurement of CD41/CD61 and CD42b Platelet Receptors and Clotting Assay of Platelet Factor 3 During Long Term-Storage of Platelet Concentrates
Background: The purpose of the present in vitro study was to evaluate the effect of long term storage of conventional platelet concentrates (PCs) on major platelet receptors CD42b and CD41/CD61 by flow cytometry method a...
The Influence of Fetal Hemoglobin on Clinical and Hematological Variables of Children and Adolescents with Sickle Cell Anemia in Basra, Southern Iraq
Background: There are many parameters that modulate the severity of sickle cell anemia. Fetal hemoglobin (Hb F) is one of these major variables. However, its effect is clinically inconsistent. We conducted a descriptive...
Evolution of Marginal Zone Lymphoma Towards Myeloproliferative Disorder: A Case Report
This article has no abstract.
Plasma Fractionation Industry Project in Turkey: Country’s Experiences
This article has no abstract.