Evaluation of 24-hour urinary citrate excretion in healthy pre-school and school-age children
Journal Title: Medycyna Ogólna i Nauki o Zdrowiu - Year 2013, Vol 19, Issue 1
Abstract
[b][/b]Introduction: Citrate is well known crystallization inhibitor of calcium-oxalate and calcium-phosphate salts in urine. Thus, decreased urinary citrate excretion is an important risk factor for urolithiasis. However, there is a lack of widely accepted normal values of urinary citrate excretion in children and adolescents.Objective: The objectives of the study were to assess 24-h urinary citrate excretion and to establish its reference values in healthy pre-school- and school-age children.Material and methods: The study comprised 211 healthy children aged 4–18 years (mean 10.9 ± 3.9 years); including 105 boys and 106 girls in age-matched groups. Urinary citrate concentration was measured enzymatically. 24-hour citrate excretion was expressed per kg of body weight, per m[sup]2[/sup] of standard body surface area and as ratio over urinary creatinine concentration.Results: A statistically significant negative correlation was noted between age and urinary citrate excretion expressed per kg of body weight or citrate/creatinine ratio. On contrary, urinary citrate excretion expressed per m[sup]2[/sup] of standard body surface area did not correlate with age. Independently of a calculation method, urinary citrate excretion was significantly higher in girls than in boys. The lowest normal urinary citrate excretion (10th percentile) for girls and boys were 1.32 mmol/1.73 m[sup]2[/sup] /24h and 0.92 mmol/1.73 m[sup]2[/sup] /24h, respectively.Conclusions: 24-hour urinary citrate excretion expressed per m[sup]2[/sup] of standard body surface area in children aged 4–18 years is constant; however, due to gender differences, reference values were established separately for boys and girls. We hope, that our results will help evaluate pediatric patients with urolithiasis.Key words: citrate, urine, children, reference values
Authors and Affiliations
Przemysław Sikora, Beata Bieniaś, Anna Wieczorkiewicz-Płaza, Paweł Szlązak, Urszula Biaduń, Maria Małgorzata Zajączkowska
Keywords
Related Articles
- EP ID EP68941
- DOI -
- Views 98
- Downloads 0
Evaluation of health promoting behaviours concerning breast cancer among women living in the Lublin Macroregion
Introduction: In our age, due to increasing social awareness, a higher level of knowledge, and progress in medicine, breast cancer is detected earlier, diagnosed, and treated. However, despite various prophylactic action...
Risk factors of low birth weight (LBW) baby – logistic regression
Introduction. Values of birth weight and percentage contribution of newborn babies with body weight below 2,500g (Low Birth Weight LBW) are mentioned among the indicators assessing the biological state of society. Aim....
Ambulatory blood pressure monitoring in children with primary and renal parenchymal hypertension
[b][/b]Introduction. Ambulatory blood pressure monitoring (ABPM) detects blood pressure disturbances more sensitively compared to casual blood pressure (BP) measurements.Objective. Assessment of differences in ABPM resul...
Aktywność fizyczna studentów fizjoterapii i dietetyki
[b]Wprowadzenie.[/b] Aktywność fizyczna to jedna z potrzeb człowieka zasadniczo wpływających na zachowanie i umacnianie zdrowia. [b]Cel.[/b] Ocena aktywności fizycznej studentów fizjoterapii i dietetyki. [b]Materiał...
Health- and nutrition-related behaviour of pupils attending sports schools in relation to their gender and body mass index – preliminary report
Introduction. Life style is one of the most important factors affecting health. Nutrition, physical activity and body mass control are life style-related issues considered as important determinants of health. Aim of th...